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General Health & Fitness
Nutrition and Supplements
Effects of coenzyme Q10 supplementation on statin‑induced myopathy
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<blockquote data-quote="xqfq" data-source="post: 201955" data-attributes="member: 38167"><p>Looking at the numbers (n=220 for the statin-induced myopathy symptom alleviation groups) - very small N.</p><p></p><p>You can see from the wide confidence interval of the muscle pain analysis - this result was "not significant" but likely underpowered. So it is "not significant" but that does not rule out the possibility that Coq10 helps with muscle pain.</p><p></p><p>There may also be questions around dose:response relationship which are unanswered by a small meta-analysis like this (I haven't read the paper but this is common). For instance, maybe 200mg a day of ubiquinol is ideal for muscle pain and some other form / lesser dosage / non-bioavailable form of the substance was used in the 4 different muscle pain studies.</p></blockquote><p></p>
[QUOTE="xqfq, post: 201955, member: 38167"] Looking at the numbers (n=220 for the statin-induced myopathy symptom alleviation groups) - very small N. You can see from the wide confidence interval of the muscle pain analysis - this result was "not significant" but likely underpowered. So it is "not significant" but that does not rule out the possibility that Coq10 helps with muscle pain. There may also be questions around dose:response relationship which are unanswered by a small meta-analysis like this (I haven't read the paper but this is common). For instance, maybe 200mg a day of ubiquinol is ideal for muscle pain and some other form / lesser dosage / non-bioavailable form of the substance was used in the 4 different muscle pain studies. [/QUOTE]
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General Health & Fitness
Nutrition and Supplements
Effects of coenzyme Q10 supplementation on statin‑induced myopathy
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