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Effects of carnitine supplementation on liver aminotransferase enzymes:
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<blockquote data-quote="madman" data-source="post: 166839" data-attributes="member: 13851"><p><strong>Effects of carnitine supplementation on liver aminotransferase enzymes: <span style="color: rgb(184, 49, 47)">A systematic review and meta-analysis of randomized controlled clinical trials </span></strong></p><p></p><p></p><p></p><p></p><p><strong>Abstract </strong></p><p></p><p><span style="color: rgb(184, 49, 47)"><strong>Background and Aims</strong> </span></p><p>This meta-analysis of the randomized controlled trials was performed to assess effects of carnitine supplementation on serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. Methods A comprehensive literature search of PubMed, Cochrane’s library, Web of Science, Scopus, and Embase was performed up to May 2018. From a total of 2012 articles identified initially, only 17 articles were included in the final meta-analysis to evaluate the effects of carnitine supplementation on serum levels of ALT and AST enzymes.</p><p></p><p><strong><span style="color: rgb(184, 49, 47)">Results </span></strong></p><p>Random effects model meta-analysis showed that carnitine supplementation led to reduction in serum ALT (weighted mean difference [WMD] − 10.25 IU/L; 95% CI = − 15.73, − 4.77; p < 0.001) and AST levels (WMD − 7.85 IU/L; 95% CI = − 11.85, − 3.86; p < 0.001).<span style="color: rgb(184, 49, 47)"> <strong>The results of subgroup analysis showed that carnitine could reduce serum AST levels at </strong></span><span style="color: rgb(44, 130, 201)"><strong>dosages equal to 2000 mg/day (p = 0.014) or more than 2000 mg/day (p < 0.001).</strong></span> However, carnitine supplementation at dosages of ≤ 1000 mg/ day (p = 0.035) or equal to 2000 mg/day (p = 0.013) resulted in significant reduction in ALT level, while doses more than 2000 mg/day did not change ALT significantly. Carnitine exerts its reducing effect on serum ALT and AST levels only when these aminotransferases are raised or when the duration of supplementation lasts at least 3 months.</p><p></p><p><span style="color: rgb(184, 49, 47)"><strong>Conclusion </strong></span></p><p><span style="color: rgb(44, 130, 201)"><strong>Results of the current meta-analysis showed that carnitine supplementation can decrease serum AST and ALT levels significantly, especially when supplementation lasts 3 months or more in patients with elevated serum aminotransferase levels. </strong></span></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">In conclusion, results of the current meta-analysis </span><span style="color: rgb(44, 130, 201)">showed that carnitine supplementation can significantly decrease serum levels of AST and ALT</span><span style="color: rgb(184, 49, 47)"> and its administration can be recommended as a useful adjuvant treatment strategy for lowering serum level of these aminotransferases in patients suffering from this condition. </span></strong></p></blockquote><p></p>
[QUOTE="madman, post: 166839, member: 13851"] [B]Effects of carnitine supplementation on liver aminotransferase enzymes: [COLOR=rgb(184, 49, 47)]A systematic review and meta-analysis of randomized controlled clinical trials [/COLOR][/B] [B]Abstract [/B] [COLOR=rgb(184, 49, 47)][B]Background and Aims[/B] [/COLOR] This meta-analysis of the randomized controlled trials was performed to assess effects of carnitine supplementation on serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. Methods A comprehensive literature search of PubMed, Cochrane’s library, Web of Science, Scopus, and Embase was performed up to May 2018. From a total of 2012 articles identified initially, only 17 articles were included in the final meta-analysis to evaluate the effects of carnitine supplementation on serum levels of ALT and AST enzymes. [B][COLOR=rgb(184, 49, 47)]Results [/COLOR][/B] Random effects model meta-analysis showed that carnitine supplementation led to reduction in serum ALT (weighted mean difference [WMD] − 10.25 IU/L; 95% CI = − 15.73, − 4.77; p < 0.001) and AST levels (WMD − 7.85 IU/L; 95% CI = − 11.85, − 3.86; p < 0.001).[COLOR=rgb(184, 49, 47)] [B]The results of subgroup analysis showed that carnitine could reduce serum AST levels at [/B][/COLOR][COLOR=rgb(44, 130, 201)][B]dosages equal to 2000 mg/day (p = 0.014) or more than 2000 mg/day (p < 0.001).[/B][/COLOR] However, carnitine supplementation at dosages of ≤ 1000 mg/ day (p = 0.035) or equal to 2000 mg/day (p = 0.013) resulted in significant reduction in ALT level, while doses more than 2000 mg/day did not change ALT significantly. Carnitine exerts its reducing effect on serum ALT and AST levels only when these aminotransferases are raised or when the duration of supplementation lasts at least 3 months. [COLOR=rgb(184, 49, 47)][B]Conclusion [/B][/COLOR] [COLOR=rgb(44, 130, 201)][B]Results of the current meta-analysis showed that carnitine supplementation can decrease serum AST and ALT levels significantly, especially when supplementation lasts 3 months or more in patients with elevated serum aminotransferase levels. [/B][/COLOR] [B][COLOR=rgb(184, 49, 47)]In conclusion, results of the current meta-analysis [/COLOR][COLOR=rgb(44, 130, 201)]showed that carnitine supplementation can significantly decrease serum levels of AST and ALT[/COLOR][COLOR=rgb(184, 49, 47)] and its administration can be recommended as a useful adjuvant treatment strategy for lowering serum level of these aminotransferases in patients suffering from this condition. [/COLOR][/B] [/QUOTE]
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Effects of carnitine supplementation on liver aminotransferase enzymes:
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