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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Effect of Testosterone Injections on Estradiol and DHT in Young and Older Men
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<blockquote data-quote="Nelson Vergel" data-source="post: 95813" data-attributes="member: 3"><p><strong>The Effects of Injected Testosterone Dose and Age on the Conversion of Testosterone to Estradiol and Dihydrotestosterone in Young and Older Men</strong></p><p></p><p></p><p>[ATTACH]4614[/ATTACH]</p><p></p><p>"<span style="color: #000000">We found that during administration of graded doses of TE, the older men had higher total and free E</span><span style="color: #000000">2 </span><span style="color: #000000">concentrations and higher total and free E</span><span style="color: #000000">2</span><span style="color: #000000">:T ratios than young men after adjusting for serum testosterone levels. In contrast to E</span><span style="color: #000000">2</span><span style="color: #000000"> levels, serum DHT levels and DHT:T ratios did not differ between young and older men. Regression modeling revealed that percentage fat mass independently and partly explained the difference in free E</span><span style="color: #000000">2</span><span style="color: #000000"> levels between young and older men, and jointly with SHBG explained most of the differences in free E</span><span style="color: #000000">2</span><span style="color: #000000"> levels as well as free E</span><span style="color: #000000">2</span><span style="color: #000000">:T ratios in the two groups. There also was an apparent effect of testosterone dose on metabolite to testosterone ratios; higher doses of testosterone were associated with seemingly lower metabolite to testosterone ratios in both young and older men. Mechanistic modeling indicated that the whole body conversion of testosterone to E</span><span style="color: #000000">2</span><span style="color: #000000"> and DHT was consistent with saturable Michaelis-Menten kinetics."</span></p><p><span style="color: #000000"></span></p><p><span style="color: #000000"></span></p><p><span style="color: #000000"></span><span style="color: #000000"><strong>Background:</strong> During testosterone (T) therapy, T is partly converted to 17&#946;-estradiol (E2) and 5&#945;-dihydrotestosterone (DHT). Effects of age, testosterone dose, and body composition on total and free E2and DHT levels are unknown.</span></p><p><span style="color: #000000"></span></p><p><span style="color: #000000"><strong>Objective:</strong> We evaluated age and dose-related differences in E2 and DHT levels in response to graded doses of testosterone enanthate in young and older men.</span></p><p><span style="color: #000000"></span></p><p><span style="color: #000000"><strong>Methods:</strong> Fifty-one young (aged 19&#8211;35 yr) and 52 older (aged 59&#8211;75 yr) men completed treatment with monthly injections of a GnRH agonist plus randomly assigned weekly doses of testosterone enanthate (25, 50, 125, 300, or 600 mg) for 5 months.</span></p><p><span style="color: #000000"></span></p><p><span style="color: #000000"><strong>Results:</strong> During testosterone administration, total and free E2 levels increased dose-dependently (dose effect, <em>P</em> < 0.001) in both young and older men. Total and free E2 levels and E2:T ratios during T administration were higher in older than young men, but age-related differences in free E2 and free E2:T ratios were not significant after adjusting for testosterone levels, percentage fat mass, and SHBG. DHT levels and DHT:T ratios were dose-related but did not differ between young and older men. Mechanistic modeling of free hormone data revealed that the conversions of T to E2 and DHT were both consistent with saturable Michaelis-Menten kinetics. The <em>in vivo</em> Km values were estimated to be 1.83 nm for aromatase and 3.35 nm for 5&#945;-reductase, independent of age. The Vmax parameter for E2 was 40% higher in older men than younger men, but Vmax for DHT was not significantly different between age groups.</span></p><p><span style="color: #000000"></span></p><p><span style="color: #000000"><strong>Conclusions:</strong> During im testosterone administration, E2 and DHT levels exhibit saturable increases with dose. The rate of whole body aromatization is higher in older men, partly related to their higher percentage fat mass, SHBG, and testosterone levels.</span></p><p><span style="color: #000000"></span></p><p><span style="color: #000000"><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913038/" target="_blank">FULL PAPER HERE</a></span></p><p><span style="color: #000000"></span></p><p><span style="color: #000000"></span></p><p><span style="color: #000000"></span></p><p><span style="color: #000000"></span></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 95813, member: 3"] [B]The Effects of Injected Testosterone Dose and Age on the Conversion of Testosterone to Estradiol and Dihydrotestosterone in Young and Older Men[/B] [ATTACH=CONFIG]4614[/ATTACH] "[COLOR=#000000][FONT='inherit']We found that during administration of graded doses of TE, the older men had higher total and free E[/FONT][/COLOR][COLOR=#000000][FONT='inherit']2 [/FONT][/COLOR][COLOR=#000000][FONT='inherit']concentrations and higher total and free E[/FONT][/COLOR][COLOR=#000000][FONT='inherit']2[/FONT][/COLOR][COLOR=#000000][FONT='inherit']:T ratios than young men after adjusting for serum testosterone levels. In contrast to E[/FONT][/COLOR][COLOR=#000000][FONT='inherit']2[/FONT][/COLOR][COLOR=#000000][FONT='inherit'] levels, serum DHT levels and DHT:T ratios did not differ between young and older men. Regression modeling revealed that percentage fat mass independently and partly explained the difference in free E[/FONT][/COLOR][COLOR=#000000][FONT='inherit']2[/FONT][/COLOR][COLOR=#000000][FONT='inherit'] levels between young and older men, and jointly with SHBG explained most of the differences in free E[/FONT][/COLOR][COLOR=#000000][FONT='inherit']2[/FONT][/COLOR][COLOR=#000000][FONT='inherit'] levels as well as free E[/FONT][/COLOR][COLOR=#000000][FONT='inherit']2[/FONT][/COLOR][COLOR=#000000][FONT='inherit']:T ratios in the two groups. There also was an apparent effect of testosterone dose on metabolite to testosterone ratios; higher doses of testosterone were associated with seemingly lower metabolite to testosterone ratios in both young and older men. Mechanistic modeling indicated that the whole body conversion of testosterone to E[/FONT][/COLOR][COLOR=#000000][FONT='inherit']2[/FONT][/COLOR][COLOR=#000000][FONT='inherit'] and DHT was consistent with saturable Michaelis-Menten kinetics." [/FONT][/COLOR][COLOR=#000000][FONT='inherit'][B]Background:[/B] During testosterone (T) therapy, T is partly converted to 17β-estradiol (E2) and 5α-dihydrotestosterone (DHT). Effects of age, testosterone dose, and body composition on total and free E2and DHT levels are unknown. [/FONT][/COLOR] [COLOR=#000000][FONT='inherit'][B]Objective:[/B] We evaluated age and dose-related differences in E2 and DHT levels in response to graded doses of testosterone enanthate in young and older men. [/FONT][/COLOR] [COLOR=#000000][FONT='inherit'][B]Methods:[/B] Fifty-one young (aged 19–35 yr) and 52 older (aged 59–75 yr) men completed treatment with monthly injections of a GnRH agonist plus randomly assigned weekly doses of testosterone enanthate (25, 50, 125, 300, or 600 mg) for 5 months. [/FONT][/COLOR] [COLOR=#000000][FONT='inherit'][B]Results:[/B] During testosterone administration, total and free E2 levels increased dose-dependently (dose effect, [I]P[/I] < 0.001) in both young and older men. Total and free E2 levels and E2:T ratios during T administration were higher in older than young men, but age-related differences in free E2 and free E2:T ratios were not significant after adjusting for testosterone levels, percentage fat mass, and SHBG. DHT levels and DHT:T ratios were dose-related but did not differ between young and older men. Mechanistic modeling of free hormone data revealed that the conversions of T to E2 and DHT were both consistent with saturable Michaelis-Menten kinetics. The [I]in vivo[/I] Km values were estimated to be 1.83 nm for aromatase and 3.35 nm for 5α-reductase, independent of age. The Vmax parameter for E2 was 40% higher in older men than younger men, but Vmax for DHT was not significantly different between age groups. [/FONT][/COLOR] [COLOR=#000000][FONT='inherit'][B]Conclusions:[/B] During im testosterone administration, E2 and DHT levels exhibit saturable increases with dose. The rate of whole body aromatization is higher in older men, partly related to their higher percentage fat mass, SHBG, and testosterone levels. [URL="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913038/"]FULL PAPER HERE[/URL][/FONT][/COLOR] [COLOR=#000000][FONT='inherit'] [/FONT][/COLOR] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Effect of Testosterone Injections on Estradiol and DHT in Young and Older Men
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