ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
General Health & Fitness
Health & Wellness
Effect of metformin on the epigenetic age
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="BigTex" data-source="post: 238007" data-attributes="member: 43589"><p><strong>Background:</strong> Metformin has been proven to have an antiaging effect. However, studies on how metformin affects global epigenetic regulation and its effect on the epigenetic clock in diabetes mellitus (DM) patients are limited. This study aims to investigate the impact of metformin on the epigenetic age in subjects with type 2 DM.</p><p></p><p><strong>Results:</strong> We collected the peripheral blood of the metformin group and the no-metformin group of the 32 DM patients. Three previously established epigenetic clocks (Hannum, Horvath, and DNAmPhenoAge) were used to estimate the epigenetic age acceleration of the two groups. We defined biological age acceleration for each group by comparing the estimated biological age with the chronological age. Results were presented as follows: 1) all three epigenetic clocks were strongly correlated with chronological age. 2) We found a strong association between metformin intake and slower epigenetic aging by Horvath’s clock and Hannum’s clock.</p><p></p><p><strong>Conclusions:</strong> Here, we found an association between metformin intake and slower epigenetic aging.</p><p></p><p><strong>FULL STUDY</strong></p><p>[URL unfurl="true"]https://www.frontiersin.org/articles/10.3389/fgene.2022.955835/full[/URL]</p><p></p><p></p><p>[URL unfurl="true"]https://www.increaselifespan.net/2022/11/02/metformin-the-old-school-anti-diabetic-that-may-prolong-life/[/URL]</p></blockquote><p></p>
[QUOTE="BigTex, post: 238007, member: 43589"] [B]Background:[/B] Metformin has been proven to have an antiaging effect. However, studies on how metformin affects global epigenetic regulation and its effect on the epigenetic clock in diabetes mellitus (DM) patients are limited. This study aims to investigate the impact of metformin on the epigenetic age in subjects with type 2 DM. [B]Results:[/B] We collected the peripheral blood of the metformin group and the no-metformin group of the 32 DM patients. Three previously established epigenetic clocks (Hannum, Horvath, and DNAmPhenoAge) were used to estimate the epigenetic age acceleration of the two groups. We defined biological age acceleration for each group by comparing the estimated biological age with the chronological age. Results were presented as follows: 1) all three epigenetic clocks were strongly correlated with chronological age. 2) We found a strong association between metformin intake and slower epigenetic aging by Horvath’s clock and Hannum’s clock. [B]Conclusions:[/B] Here, we found an association between metformin intake and slower epigenetic aging. [B]FULL STUDY[/B] [URL unfurl="true"]https://www.frontiersin.org/articles/10.3389/fgene.2022.955835/full[/URL] [URL unfurl="true"]https://www.increaselifespan.net/2022/11/02/metformin-the-old-school-anti-diabetic-that-may-prolong-life/[/URL] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
General Health & Fitness
Health & Wellness
Effect of metformin on the epigenetic age
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top