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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Effect of a single injection of testosterone enanthate on 17β estradiol and bone turnover markers
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<blockquote data-quote="Nelson Vergel" data-source="post: 11929" data-attributes="member: 3"><p><strong>Effect of a single injection of testosterone enanthate on 17β estradiol and bone turnover markers</strong></p><p></p><p>It is interesting to see for the first time that some men do not have increases in estradiol after a shot of testosterone. 9 out of 21 were in this group. They are also the ones with lower T peak values.</p><p></p><p>I have not read the whole paper to see what estradiol test they used and if there is something in those 9 men that differentiates them from the rest at baseline.</p><p></p><p>Effect of a single injection of testosterone enanthate on 17β estradiol and bone turnover markers in hypogonadal male patients.</p><p></p><p>Camozzi V, et al</p><p>J Endocrinol Invest. 2014 Oct 16. [Epub ahead of print]</p><p></p><p>Abstract</p><p></p><p>PURPOSE: Several clinical studies testify the critical role played by estrogens in male bone metabolism. The aim of our study is to assess the effect of a single injection of testosterone enanthate in a group of hypogonadal men on 17β estradiol serum levels and some bone metabolic parameters.</p><p></p><p>METHOD: Twenty-one hypogonadal males were given one testosterone enanthate injection (250 mg). Blood samples were drawn before the injection and after 1, 2 and 3 weeks. The following variables were measured: Total testosterone (TT), 17β estradiol (17β E2), Sex hormone binding globulin, total alkaline phosphatase, osteocalcin, and C-telopeptide of type I collagen (CTx).</p><p></p><p>RESULTS: <strong>After testosterone injection, both TT and 17β E2 increased, peaking 1 week after the injection. Individual observation of the response of 17β E2 to testosterone showed that a subgroup (n = 9) failed to respond with any increase in 17β E2 at any of the weekly tests (group E2-), while the remainder (n = 12) showed a significant increase in 17β E2, which reached a mean value three times higher than at baseline (group E2+). </strong>The E2- patients reached a TT peak lower than that observed in the E+ group. CTx serum levels declined progressively in the E2+ group, reaching the significance (p = 0.03) at the end of the study, while it did not change in E- group.</p><p></p><p>CONCLUSION: This study suggests that a single injection of testosterone might have different effects on the production of endogenous estrogens, and a significant reduction of bone resorption parameters takes place only in the patients who show a significant increase of 17ß estradiol in response to testosterone administration.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 11929, member: 3"] [b]Effect of a single injection of testosterone enanthate on 17β estradiol and bone turnover markers[/b] It is interesting to see for the first time that some men do not have increases in estradiol after a shot of testosterone. 9 out of 21 were in this group. They are also the ones with lower T peak values. I have not read the whole paper to see what estradiol test they used and if there is something in those 9 men that differentiates them from the rest at baseline. Effect of a single injection of testosterone enanthate on 17β estradiol and bone turnover markers in hypogonadal male patients. Camozzi V, et al J Endocrinol Invest. 2014 Oct 16. [Epub ahead of print] Abstract PURPOSE: Several clinical studies testify the critical role played by estrogens in male bone metabolism. The aim of our study is to assess the effect of a single injection of testosterone enanthate in a group of hypogonadal men on 17β estradiol serum levels and some bone metabolic parameters. METHOD: Twenty-one hypogonadal males were given one testosterone enanthate injection (250 mg). Blood samples were drawn before the injection and after 1, 2 and 3 weeks. The following variables were measured: Total testosterone (TT), 17β estradiol (17β E2), Sex hormone binding globulin, total alkaline phosphatase, osteocalcin, and C-telopeptide of type I collagen (CTx). RESULTS: [B]After testosterone injection, both TT and 17β E2 increased, peaking 1 week after the injection. Individual observation of the response of 17β E2 to testosterone showed that a subgroup (n = 9) failed to respond with any increase in 17β E2 at any of the weekly tests (group E2-), while the remainder (n = 12) showed a significant increase in 17β E2, which reached a mean value three times higher than at baseline (group E2+). [/B]The E2- patients reached a TT peak lower than that observed in the E+ group. CTx serum levels declined progressively in the E2+ group, reaching the significance (p = 0.03) at the end of the study, while it did not change in E- group. CONCLUSION: This study suggests that a single injection of testosterone might have different effects on the production of endogenous estrogens, and a significant reduction of bone resorption parameters takes place only in the patients who show a significant increase of 17ß estradiol in response to testosterone administration. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Effect of a single injection of testosterone enanthate on 17β estradiol and bone turnover markers
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