ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
ED Resistant to Treatment Caused by Penile Leakage
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 189299" data-attributes="member: 13851"><p><strong>Erectile Dysfunction Resistant to Medical Treatment Caused by Cavernovenous Leakage: <span style="color: rgb(184, 49, 47)">An Innovative Surgical Approach Combining Preoperative Work Up, Embolisation, and Open Surgery </span></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>WHAT THIS PAPER ADDS</strong> <em><span style="color: rgb(184, 49, 47)"><strong>This paper provides a pre-operative workup and treatment scheme for cavernovenous leakage,</strong> </span><span style="color: rgb(44, 130, 201)"><strong><u>a frequent, albeit ignored, disease responsible for erectile dysfunction (ED) resistant to oral treatment</u> (i.e. 30% of patients eligible for ED medications). </strong></span></em><strong><em><span style="color: rgb(184, 49, 47)">Arterial and venous penis pharmacologically challenged duplex sonography and cavernoscanner, followed by an intervention combining endovascular embolization and open surgery allow 82% of patients to perform intercourse with penetration, including those with diabetes.</span></em></strong><em><span style="color: rgb(184, 49, 47)"><strong> The correlations between penile hemodynamics and erectile function are documented here for the first time.</strong></span></em></p><p></p><p></p><p><strong>Objective: </strong><em><span style="color: rgb(184, 49, 47)"><u><strong>Thirty per cent of cases of erectile dysfunction (ED)/male impotence are resistant to oral treatment. Half of these cases are due to blood drainage from the corpora cavernosa occurring too soon, due to cavernovenous leakage (CVL)</strong></u><strong>.</strong> </span></em><span style="color: rgb(44, 130, 201)"><em><strong>The aim of this study was to report on an innovative treatment scheme combining pre- and post-operative haemodynamic assessment, venous embolisation, and open surgery for drug-resistant ED caused by CVL. </strong></em></span></p><p></p><p><strong>Methods:</strong> An analysis of prospectively collected data, with clinical and haemodynamic pre- and post-operative assessment, was carried out. Forty-five consecutive patients operated on for drug-resistant ED caused by CVL were evaluated pre-operatively and three months post-operatively by pharmacologically challenged penile duplex sonography (PC-PDS), pharmacologically challenged Erection Hardness Score (PC-EHS) and pharmacologically challenged computed caverno tomography (PC-CCT). Follow up consisted of a patient interview, PC-PDS, PC-EHS and if needed PC-CCT.</p><p></p><p><strong>Results: </strong>Mean patient age was 43.9 <em>± </em>12.0 years (range 20-67). Forty-nine per cent of patients had primary ED. Patients with diabetes, a smoking habit, hypercholesterolaemia, and hypertension were 18%, 11%, 9%, and 4%, respectively. Three months post-operatively, PC-EHS increased from 2.0 <em>±</em> 0.7 to 3.1 <em>±</em> 0.74 (p < .001), with an EHS of 3 being the threshold allowing for penetration. Deep dorsal vein velocity, a haemodynamic marker of CVL, decreased from 14.2 <em>±</em> 13.0 to 0.9 <em>±</em> 3.5 cm/s (p < .001). After a 14.0 <em>±</em> 10.7 month follows up, the primary success rate (clinical EHS ≥ 3, possible sexual intercourse with penetration, no vascular re-operation, no penile prosthesis implant) was 73.3%. Four patients (9%) underwent successful re-operation for persistent ED and CVL. Accordingly, compared with a possible penetration rate of 8.9% before surgery, 37 patients (secondary success rate: 82.2%) were able to achieve sexual intercourse with penetration. Type of ED (primary vs. secondary) and diabetes had no influence on the results. Thirty-two per cent of patients with the secondary success achieved penetration with no medication.</p><p></p><p><strong>Conclusions:</strong> <em><span style="color: rgb(184, 49, 47)">After a 14 month follow up, pre-operative workup, embolisation, and open surgery during the same procedure allowed patients with ED resistant to oral medications to achieve intercourse with penetration.</span></em></p><p></p><p></p><p><strong>INTRODUCTION </strong></p><p></p><p><em><span style="color: rgb(184, 49, 47)"><u>Erectile dysfunction (ED) caused by cavernovenous leakage (CVL) is a vascular disease of the penis in which blood fails to accumulate in the corpora cavernosa (CC) because of the abrupt drainage of blood from the penis due to an abnormal venous network</u>.1,2 As a consequence, pressure in the CC does not rise and any erection is insufficient to achieve intromission during sexual intercourse.</span></em></p><p><em><span style="color: rgb(184, 49, 47)"></span></em></p><p><em><span style="color: rgb(184, 49, 47)">Papaverine intracavernosal injections (ICIs)3 and oral medications, introduced 21 years ago,4 have revolutionised the medical treatment of ED. </span></em><span style="color: rgb(184, 49, 47)"><em><u>However, oral treatments are ineffective in 30% of patients with ED;5,6 in half of these cases CVL is responsible for the failure to retain blood in the penis, despite a drug-induced increase in inflow</u>.7,8 Up to 86% of patients resistant to papaverine or prostaglandin E1 ICIs have CVL.9,10 CVL is responsible for half of the cases of severe ED, which affects 1%e4% of men under 25 years of age.11,12 Despite its high prevalence, CVL usually remains hidden.</em> <em>Consequently, patients (potentially young ones) with drug-resistant ED who refuse (if proposed) penile implants are unable to achieve sexual intercourse.</em></span></p><p></p><p>ICIs to induce erections have promoted the concept of somatic causes of ED,13 and have provided pharmacological tools to unravel the causes of ED. A combination of pharmacologically challenged (PC) duplex sonography (PCPDS),14e16 PC cavernoscanner (PC-CCT),17,18 and Erection Hardness Score (EHS) provide an accurate diagnosis of CVL and assessment of treatment efficacy.</p><p></p><p>Surgery for CVL has been nearly completely abandoned, except in notable exceptions.19e22 Most reports suggest that surgical or embolisation procedures alone are ineffective for reasons ranging from flawed patient selection,23 poor follow up, and early recurrent post-operative CVL.23e 26 It was thought that improved haemodynamic and morphological disease characterisation, together with an innovative combination of open and endovascular techniques during the same procedure, may result in a more efficient blockade of venous outflow.</p><p></p><p><em><span style="color: rgb(184, 49, 47)"><strong>A series of patients with CVL, all resistant to oral treatment, assessed before and after the intervention, who were operated on with a combination of open and endovascular techniques, is presented. </strong></span></em></p><p></p><p></p><p><strong>DISCUSSION </strong></p><p><strong></strong></p><p><strong><em><span style="color: rgb(44, 130, 201)">This paper has reported on a new treatment scheme for patients with ED resistant to medical treatment, consisting of a rigorous pre- and post-operative haemodynamic assessment; leaking vein visualisation with PC-CCT; and an innovative association between embolisation and open surgery during the same procedure. The main result is improved erectile function, allowing 82% of patients to achieve sexual intercourse with penetration after a 14 month follow up.</span></em></strong></p><p><strong></strong></p><p><strong>Cavernovenous leakage diagnosis and characterisation </strong></p><p></p><p><span style="color: rgb(184, 49, 47)"><em><strong>Because of the vascular nature of erectile tissue,27,30e32 standardised PC-PDS discriminates vascular from psychological and neurological causes of ED:</strong></em></span> <span style="color: rgb(44, 130, 201)"><em><strong>patients responding with weak erections to pharmacological stimulation are likely to suffer from vascular disease,27 whereas those with a strong erectile response can be considered to have a functional penile vascular system.</strong></em></span> <span style="color: rgb(184, 49, 47)"><em><strong>PC-PDS provides quantitative information on the penis’s ability to retain blood in the CCs, the function compromised in CVL. In order to avoid false-positive diagnoses, a diagnosis of CVL was retained in patients with no or minor arterial disease, after sufficient pharmacological stimulation,10,27 and direct penis haemodynamic assessment of leaking veins.27 PC-CCT and three-dimensional reconstructions allow for a personalised operative strategy.17,18 </strong></em></span></p><p></p><p></p><p></p><p><strong><span style="color: rgb(0, 0, 0)">Conclusion </span></strong></p><p></p><p><span style="color: rgb(184, 49, 47)"><em><strong>Evidence is provided that the association between embolisation and open surgery efficiently addresses CVL responsible for ED resistant to medical treatment. CVL can be diagnosed at all ages of sexual life, with a prevalence of 1%-2% in those <25 years and of 10%-20% after 60 years of age. State of the art pre-operative patient selection is critical. </strong></em></span><span style="color: rgb(44, 130, 201)"><em><strong><u>Although a longer follow up is awaited, the youngest of the patients in the present series who had never experienced sexual intercourse now have access to a full sex life. These results justify PC-PDS detection of CVL in drug-resistant EDs at all ages, including in diabetic patients</u>. This research is now aimed at understanding the mechanisms of surgery failures. </strong></em></span></p></blockquote><p></p>
[QUOTE="madman, post: 189299, member: 13851"] [B]Erectile Dysfunction Resistant to Medical Treatment Caused by Cavernovenous Leakage: [COLOR=rgb(184, 49, 47)]An Innovative Surgical Approach Combining Preoperative Work Up, Embolisation, and Open Surgery [/COLOR] WHAT THIS PAPER ADDS[/B] [I][COLOR=rgb(184, 49, 47)][B]This paper provides a pre-operative workup and treatment scheme for cavernovenous leakage,[/B] [/COLOR][COLOR=rgb(44, 130, 201)][B][U]a frequent, albeit ignored, disease responsible for erectile dysfunction (ED) resistant to oral treatment[/U] (i.e. 30% of patients eligible for ED medications). [/B][/COLOR][/I][B][I][COLOR=rgb(184, 49, 47)]Arterial and venous penis pharmacologically challenged duplex sonography and cavernoscanner, followed by an intervention combining endovascular embolization and open surgery allow 82% of patients to perform intercourse with penetration, including those with diabetes.[/COLOR][/I][/B][I][COLOR=rgb(184, 49, 47)][B] The correlations between penile hemodynamics and erectile function are documented here for the first time.[/B][/COLOR][/I] [B]Objective: [/B][I][COLOR=rgb(184, 49, 47)][U][B]Thirty per cent of cases of erectile dysfunction (ED)/male impotence are resistant to oral treatment. Half of these cases are due to blood drainage from the corpora cavernosa occurring too soon, due to cavernovenous leakage (CVL)[/B][/U][B].[/B] [/COLOR][/I][COLOR=rgb(44, 130, 201)][I][B]The aim of this study was to report on an innovative treatment scheme combining pre- and post-operative haemodynamic assessment, venous embolisation, and open surgery for drug-resistant ED caused by CVL. [/B][/I][/COLOR] [B]Methods:[/B] An analysis of prospectively collected data, with clinical and haemodynamic pre- and post-operative assessment, was carried out. Forty-five consecutive patients operated on for drug-resistant ED caused by CVL were evaluated pre-operatively and three months post-operatively by pharmacologically challenged penile duplex sonography (PC-PDS), pharmacologically challenged Erection Hardness Score (PC-EHS) and pharmacologically challenged computed caverno tomography (PC-CCT). Follow up consisted of a patient interview, PC-PDS, PC-EHS and if needed PC-CCT. [B]Results: [/B]Mean patient age was 43.9 [I]± [/I]12.0 years (range 20-67). Forty-nine per cent of patients had primary ED. Patients with diabetes, a smoking habit, hypercholesterolaemia, and hypertension were 18%, 11%, 9%, and 4%, respectively. Three months post-operatively, PC-EHS increased from 2.0 [I]±[/I] 0.7 to 3.1 [I]±[/I] 0.74 (p < .001), with an EHS of 3 being the threshold allowing for penetration. Deep dorsal vein velocity, a haemodynamic marker of CVL, decreased from 14.2 [I]±[/I] 13.0 to 0.9 [I]±[/I] 3.5 cm/s (p < .001). After a 14.0 [I]±[/I] 10.7 month follows up, the primary success rate (clinical EHS ≥ 3, possible sexual intercourse with penetration, no vascular re-operation, no penile prosthesis implant) was 73.3%. Four patients (9%) underwent successful re-operation for persistent ED and CVL. Accordingly, compared with a possible penetration rate of 8.9% before surgery, 37 patients (secondary success rate: 82.2%) were able to achieve sexual intercourse with penetration. Type of ED (primary vs. secondary) and diabetes had no influence on the results. Thirty-two per cent of patients with the secondary success achieved penetration with no medication. [B]Conclusions:[/B] [I][COLOR=rgb(184, 49, 47)]After a 14 month follow up, pre-operative workup, embolisation, and open surgery during the same procedure allowed patients with ED resistant to oral medications to achieve intercourse with penetration.[/COLOR][/I] [B]INTRODUCTION [/B] [I][COLOR=rgb(184, 49, 47)][U]Erectile dysfunction (ED) caused by cavernovenous leakage (CVL) is a vascular disease of the penis in which blood fails to accumulate in the corpora cavernosa (CC) because of the abrupt drainage of blood from the penis due to an abnormal venous network[/U].1,2 As a consequence, pressure in the CC does not rise and any erection is insufficient to achieve intromission during sexual intercourse. Papaverine intracavernosal injections (ICIs)3 and oral medications, introduced 21 years ago,4 have revolutionised the medical treatment of ED. [/COLOR][/I][COLOR=rgb(184, 49, 47)][I][U]However, oral treatments are ineffective in 30% of patients with ED;5,6 in half of these cases CVL is responsible for the failure to retain blood in the penis, despite a drug-induced increase in inflow[/U].7,8 Up to 86% of patients resistant to papaverine or prostaglandin E1 ICIs have CVL.9,10 CVL is responsible for half of the cases of severe ED, which affects 1%e4% of men under 25 years of age.11,12 Despite its high prevalence, CVL usually remains hidden.[/I] [I]Consequently, patients (potentially young ones) with drug-resistant ED who refuse (if proposed) penile implants are unable to achieve sexual intercourse.[/I][/COLOR] ICIs to induce erections have promoted the concept of somatic causes of ED,13 and have provided pharmacological tools to unravel the causes of ED. A combination of pharmacologically challenged (PC) duplex sonography (PCPDS),14e16 PC cavernoscanner (PC-CCT),17,18 and Erection Hardness Score (EHS) provide an accurate diagnosis of CVL and assessment of treatment efficacy. Surgery for CVL has been nearly completely abandoned, except in notable exceptions.19e22 Most reports suggest that surgical or embolisation procedures alone are ineffective for reasons ranging from flawed patient selection,23 poor follow up, and early recurrent post-operative CVL.23e 26 It was thought that improved haemodynamic and morphological disease characterisation, together with an innovative combination of open and endovascular techniques during the same procedure, may result in a more efficient blockade of venous outflow. [I][COLOR=rgb(184, 49, 47)][B]A series of patients with CVL, all resistant to oral treatment, assessed before and after the intervention, who were operated on with a combination of open and endovascular techniques, is presented. [/B][/COLOR][/I] [B]DISCUSSION [I][COLOR=rgb(44, 130, 201)]This paper has reported on a new treatment scheme for patients with ED resistant to medical treatment, consisting of a rigorous pre- and post-operative haemodynamic assessment; leaking vein visualisation with PC-CCT; and an innovative association between embolisation and open surgery during the same procedure. The main result is improved erectile function, allowing 82% of patients to achieve sexual intercourse with penetration after a 14 month follow up.[/COLOR][/I] Cavernovenous leakage diagnosis and characterisation [/B] [COLOR=rgb(184, 49, 47)][I][B]Because of the vascular nature of erectile tissue,27,30e32 standardised PC-PDS discriminates vascular from psychological and neurological causes of ED:[/B][/I][/COLOR] [COLOR=rgb(44, 130, 201)][I][B]patients responding with weak erections to pharmacological stimulation are likely to suffer from vascular disease,27 whereas those with a strong erectile response can be considered to have a functional penile vascular system.[/B][/I][/COLOR] [COLOR=rgb(184, 49, 47)][I][B]PC-PDS provides quantitative information on the penis’s ability to retain blood in the CCs, the function compromised in CVL. In order to avoid false-positive diagnoses, a diagnosis of CVL was retained in patients with no or minor arterial disease, after sufficient pharmacological stimulation,10,27 and direct penis haemodynamic assessment of leaking veins.27 PC-CCT and three-dimensional reconstructions allow for a personalised operative strategy.17,18 [/B][/I][/COLOR] [B][COLOR=rgb(0, 0, 0)]Conclusion [/COLOR][/B] [COLOR=rgb(184, 49, 47)][I][B]Evidence is provided that the association between embolisation and open surgery efficiently addresses CVL responsible for ED resistant to medical treatment. CVL can be diagnosed at all ages of sexual life, with a prevalence of 1%-2% in those <25 years and of 10%-20% after 60 years of age. State of the art pre-operative patient selection is critical. [/B][/I][/COLOR][COLOR=rgb(44, 130, 201)][I][B][U]Although a longer follow up is awaited, the youngest of the patients in the present series who had never experienced sexual intercourse now have access to a full sex life. These results justify PC-PDS detection of CVL in drug-resistant EDs at all ages, including in diabetic patients[/U]. This research is now aimed at understanding the mechanisms of surgery failures. [/B][/I][/COLOR] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
ED Resistant to Treatment Caused by Penile Leakage
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top