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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
ED ongoing issues
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<blockquote data-quote="Cataceous" data-source="post: 154901" data-attributes="member: 38109"><p>Your numbers do seem to illustrate the concept nicely, provided some assumptions hold. To compare the two sets of numbers directly we're assuming that the rate of absorption of testosterone is roughly the same each time. This is probably the case because you're on the same protocol and presumably taking measurements at the same point in the injection cycle. The bigger assumption is that with respect to factors that influence the clearance rate of testosterone, only SHBG has changed. Further, we're assuming a localized steady state in testosterone, wherein the rate of absorption of testosterone is equal to the rate of clearance.</p><p></p><p>Under these conditions it's clear that free testosterone can't change, except briefly during transitions. This is because the clearance rate of testosterone is proportional to free testosterone, and we've required that the clearance rate be fixed—to match the absorption rate.</p><p></p><p>So what happens when SHBG goes down, as in your case? This starts to push up free testosterone, which starts to increase the clearance rate. But these trends are counteracted by the fixed absorption rate, which forces total testosterone down to a lower equilibrium value so that the clearance rate returns to its original value, matching the absorption rate.</p><p></p><p>I went through the arguments in more detail using an analogy to tubs of water: <a href="https://www.excelmale.com/forum/threads/trt-with-or-without-hcg-and-ai.19002/post-151781" target="_blank">[1]</a>, <a href="https://www.excelmale.com/forum/threads/how-long-after-the-t-injection-are-t-levels-the-highest.19084/post-152706" target="_blank">[2]</a></p><p>The math in particular is <a href="https://www.excelmale.com/forum/threads/how-long-after-the-t-injection-are-t-levels-the-highest.19084/post-152727" target="_blank">here</a>.</p><p></p><p>There's an interesting complication with your free testosterone numbers. "madman" has been complaining that you're using an inaccurate free T test, and indeed the numbers don't seem to match either Vermeulen or Tru-T. However, it appears that Quest is doing some kind of calculation based on total T, SHBG and albumin <a href="https://testdirectory.questdiagnostics.com/test/test-detail/18944/?cc=AMD" target="_blank">[3]</a>, so maybe these numbers should not be dismissed so quickly.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 154901, member: 38109"] Your numbers do seem to illustrate the concept nicely, provided some assumptions hold. To compare the two sets of numbers directly we're assuming that the rate of absorption of testosterone is roughly the same each time. This is probably the case because you're on the same protocol and presumably taking measurements at the same point in the injection cycle. The bigger assumption is that with respect to factors that influence the clearance rate of testosterone, only SHBG has changed. Further, we're assuming a localized steady state in testosterone, wherein the rate of absorption of testosterone is equal to the rate of clearance. Under these conditions it's clear that free testosterone can't change, except briefly during transitions. This is because the clearance rate of testosterone is proportional to free testosterone, and we've required that the clearance rate be fixed—to match the absorption rate. So what happens when SHBG goes down, as in your case? This starts to push up free testosterone, which starts to increase the clearance rate. But these trends are counteracted by the fixed absorption rate, which forces total testosterone down to a lower equilibrium value so that the clearance rate returns to its original value, matching the absorption rate. I went through the arguments in more detail using an analogy to tubs of water: [URL='https://www.excelmale.com/forum/threads/trt-with-or-without-hcg-and-ai.19002/post-151781'][1][/URL], [URL='https://www.excelmale.com/forum/threads/how-long-after-the-t-injection-are-t-levels-the-highest.19084/post-152706'][2][/URL] The math in particular is [URL='https://www.excelmale.com/forum/threads/how-long-after-the-t-injection-are-t-levels-the-highest.19084/post-152727']here[/URL]. There's an interesting complication with your free testosterone numbers. "madman" has been complaining that you're using an inaccurate free T test, and indeed the numbers don't seem to match either Vermeulen or Tru-T. However, it appears that Quest is doing some kind of calculation based on total T, SHBG and albumin [URL='https://testdirectory.questdiagnostics.com/test/test-detail/18944/?cc=AMD'][3][/URL], so maybe these numbers should not be dismissed so quickly. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
ED ongoing issues
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