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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
ED: Key Role of Cavernous Smooth Muscle Cells
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<blockquote data-quote="madman" data-source="post: 228742" data-attributes="member: 13851"><p><strong>FIGURE 4 | <u>Pharmacomechanical mechanism of relaxation in the cavernous smooth muscle by activation of NO-sGC-PKG and Gs-AC-PKA pathways</u>. NANC: non-adrenergic non-cholinergic transmission; [Ca2+]i : intracellular Ca2+ concentration; CaM: calmodulin protein; nNOS: neuronal nitric oxide synthase; NO: nitric oxide; CaV: voltage-dependent Ca2+ channels; eNOS: endothelial nitric oxide synthase; PGI2: prostacyclin; PGE1/2: prostaglandins E types 1 and 2; AC: adenylyl cyclase; ATP: adenosine triphosphate; cAMP: cyclic adenosine monophosphate; PKA: cAMP-dependent protein kinase; AMP: adenosine monophosphate; sGC: soluble guanylyl cyclase receptor; GTP: guanosine triphosphate; cGMP: cyclic guanosine monophosphate; PKG: cGMP-dependent protein kinase; GMP: guanosine monophosphate; IP3: inositol 1,4,5-trisphosphate; SR: sarcoplasmic reticulum; SERCA: Ca2+-ATPase of sarcoplasmic reticulum; CaV: voltage-dependent Ca2+ channels; MLCK: myosin light chain kinase; NCX: Na+ /Ca2+ exchanger; PMCA: Ca2+-ATPase of plasma membrane; PDE: phosphodiesterase enzyme.</strong></p><p><strong>[ATTACH=full]23762[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 228742, member: 13851"] [B]FIGURE 4 | [U]Pharmacomechanical mechanism of relaxation in the cavernous smooth muscle by activation of NO-sGC-PKG and Gs-AC-PKA pathways[/U]. NANC: non-adrenergic non-cholinergic transmission; [Ca2+]i : intracellular Ca2+ concentration; CaM: calmodulin protein; nNOS: neuronal nitric oxide synthase; NO: nitric oxide; CaV: voltage-dependent Ca2+ channels; eNOS: endothelial nitric oxide synthase; PGI2: prostacyclin; PGE1/2: prostaglandins E types 1 and 2; AC: adenylyl cyclase; ATP: adenosine triphosphate; cAMP: cyclic adenosine monophosphate; PKA: cAMP-dependent protein kinase; AMP: adenosine monophosphate; sGC: soluble guanylyl cyclase receptor; GTP: guanosine triphosphate; cGMP: cyclic guanosine monophosphate; PKG: cGMP-dependent protein kinase; GMP: guanosine monophosphate; IP3: inositol 1,4,5-trisphosphate; SR: sarcoplasmic reticulum; SERCA: Ca2+-ATPase of sarcoplasmic reticulum; CaV: voltage-dependent Ca2+ channels; MLCK: myosin light chain kinase; NCX: Na+ /Ca2+ exchanger; PMCA: Ca2+-ATPase of plasma membrane; PDE: phosphodiesterase enzyme. [ATTACH type="full"]23762[/ATTACH][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
ED: Key Role of Cavernous Smooth Muscle Cells
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