ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
ED in Men on the Rise: Is There a Link with Endocrine Disrupting Chemicals?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 211226" data-attributes="member: 13851"><p><strong>Fig. 5. <u>Estrogen-mediated positive regulation of eNOS expression/activation</u>. In the endothelial cell, when the estrogen receptor (ER) binds to the estrogen ligand (endogenous or exogenous estrogen or estrogen-mimicking EDCs; green circle), it dimerizes and translocates to the nucleus where it binds to an estrogen-response element (ERE) in the NOS3 promoter. This induces transcription of NOS3 which leads to the production of endothelial nitric oxide synthase (eNOS). In addition, the association of membrane-bound estrogen receptors (mERs) with estrogen initiates rapid, non-genomic signaling. This involves activation of the phosphoinositide 3-kinase/ protein kinase B (PI3K/Akt) pathway, which in turn activates eNOS by phosphorylation so that it produces NO. NO is the same as shown in Figure 4</strong></p><p>[ATTACH=full]17380[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 211226, member: 13851"] [B]Fig. 5. [U]Estrogen-mediated positive regulation of eNOS expression/activation[/U]. In the endothelial cell, when the estrogen receptor (ER) binds to the estrogen ligand (endogenous or exogenous estrogen or estrogen-mimicking EDCs; green circle), it dimerizes and translocates to the nucleus where it binds to an estrogen-response element (ERE) in the NOS3 promoter. This induces transcription of NOS3 which leads to the production of endothelial nitric oxide synthase (eNOS). In addition, the association of membrane-bound estrogen receptors (mERs) with estrogen initiates rapid, non-genomic signaling. This involves activation of the phosphoinositide 3-kinase/ protein kinase B (PI3K/Akt) pathway, which in turn activates eNOS by phosphorylation so that it produces NO. NO is the same as shown in Figure 4[/B] [ATTACH type="full" alt="Screenshot (8832).png"]17380[/ATTACH] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
X (Twitter)
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
ED in Men on the Rise: Is There a Link with Endocrine Disrupting Chemicals?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top