I used to wake up only once a night to go pee. Sometime around the age of 52 about a year into TRT I suddenly started waking up more than once. Overtime I noticed that I would have difficulties getting back to sleep on the second wake up. Investigated everything- BPH, apnea, pelvic floor issues... nothing fixed it. I finally went off the TRT. What I found is I still wake up multiple times at night but now I can fall back asleep. I’ve concluded that my sleep issues are due to aging (I’m now almost 57) and have had to adapt by improving my sleep hygiene, developing good evening pre sleep routines, going to bed earlier, and allowing myself to get up later.