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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Early Clomid Results - Thoughts?
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<blockquote data-quote="AbsoluteZ3R0" data-source="post: 72228" data-attributes="member: 15174"><p>I'm not a medical professional, so this is just my conjecture. To me, it looks like somewhat of a hybrid issue. As you know, primary hypogonadism is failure of the Leydig cells in the testes, and secondary hypogonadism is failure of the pituitary gland. Looking strictly at your son's blood work, I would have guessed that it was purely primary hypogonadism. An LH of 4.5 is healthy and would typically result in normal testosterone levels. However, if he has had pituitary issues his whole life, then lifelong under-stimulation of the testes might have result in weak/under-developed Leydig cells that don't respond as well to LH. It's also possible that his FSH (which wasn't tested) is low, which would also contribute to reduced testicular function. Was his testicular volume measured before starting clomid? That might have given some clues as to what the issue is. Regardless, the clomid seems to be working quite well, quadrupling his testosterone levels. If my conjecture is correct, his testicles will eventually adapt and start responding better to the clomid, unless for whatever reason the Leydig cells stay permanently underdeveloped. Assuming his testicles "restart," his LH will remain elevated due to the clomid, but probably not as much, because it will take less of it to create more testosterone/estrogen.</p><p></p><p>Estrogen reference range looks like it was measured via the standard estradiol test, rather than the sensitive. The standard test will show an inflated estradiol measurement. A lot of guys on clomid report not feeling any better or different than when they were purely hypogonadal. I personally felt better hypogonadal than even on a low dose of clomid, although I never took it with an AI. That said, hormonal responses take some time and even if he responds well to the clomid, it may take longer than 3 weeks before he experiences subjective improvement. I wish you and him the best of luck.</p></blockquote><p></p>
[QUOTE="AbsoluteZ3R0, post: 72228, member: 15174"] I'm not a medical professional, so this is just my conjecture. To me, it looks like somewhat of a hybrid issue. As you know, primary hypogonadism is failure of the Leydig cells in the testes, and secondary hypogonadism is failure of the pituitary gland. Looking strictly at your son's blood work, I would have guessed that it was purely primary hypogonadism. An LH of 4.5 is healthy and would typically result in normal testosterone levels. However, if he has had pituitary issues his whole life, then lifelong under-stimulation of the testes might have result in weak/under-developed Leydig cells that don't respond as well to LH. It's also possible that his FSH (which wasn't tested) is low, which would also contribute to reduced testicular function. Was his testicular volume measured before starting clomid? That might have given some clues as to what the issue is. Regardless, the clomid seems to be working quite well, quadrupling his testosterone levels. If my conjecture is correct, his testicles will eventually adapt and start responding better to the clomid, unless for whatever reason the Leydig cells stay permanently underdeveloped. Assuming his testicles "restart," his LH will remain elevated due to the clomid, but probably not as much, because it will take less of it to create more testosterone/estrogen. Estrogen reference range looks like it was measured via the standard estradiol test, rather than the sensitive. The standard test will show an inflated estradiol measurement. A lot of guys on clomid report not feeling any better or different than when they were purely hypogonadal. I personally felt better hypogonadal than even on a low dose of clomid, although I never took it with an AI. That said, hormonal responses take some time and even if he responds well to the clomid, it may take longer than 3 weeks before he experiences subjective improvement. I wish you and him the best of luck. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Early Clomid Results - Thoughts?
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