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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
E2: what is "high" and "low"
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<blockquote data-quote="Cataceous" data-source="post: 201417" data-attributes="member: 38109"><p><em>TRT is associated with external, physical changes in the men. Exogenous testosterone is known to cause an imbalance in the hypothalamic-pituitary axis. As such, testosterone can be converted to estrogen by aromatization. Excess estrogens may lead to gynecomastia and/or breast pain, both of which may be seen in 10-25% of men on TRT.[<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897047/#ref66" target="_blank">66</a>] The ratio of estradiol to androgens is the key factor in the development of gynecomastia rather than absolute increases in androgens themselves.[<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897047/#ref66" target="_blank">66</a>] Clinicians must be aware of non-iatrogenic causes of gynecomastia and therefore the appropriate work-up should be sought out to rule out other pathology, especially if there is any breast tenderness or unilateral gynecomastia. Only a few case-reports describe a relationship between male breast cancer and TRT.[<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897047/#ref38" target="_blank">38</a>,<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897047/#ref39" target="_blank">39</a>]</em></p><p></p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897047/[/URL]</p><p></p><p>Your aromatization rate is over 0.8%, certainly on the high side. Most likely it's the hCG that's pushing it up. Excess emotionalism is a common symptom.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 201417, member: 38109"] [I]TRT is associated with external, physical changes in the men. Exogenous testosterone is known to cause an imbalance in the hypothalamic-pituitary axis. As such, testosterone can be converted to estrogen by aromatization. Excess estrogens may lead to gynecomastia and/or breast pain, both of which may be seen in 10-25% of men on TRT.[[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897047/#ref66']66[/URL]] The ratio of estradiol to androgens is the key factor in the development of gynecomastia rather than absolute increases in androgens themselves.[[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897047/#ref66']66[/URL]] Clinicians must be aware of non-iatrogenic causes of gynecomastia and therefore the appropriate work-up should be sought out to rule out other pathology, especially if there is any breast tenderness or unilateral gynecomastia. Only a few case-reports describe a relationship between male breast cancer and TRT.[[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897047/#ref38']38[/URL],[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897047/#ref39']39[/URL]][/I] [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897047/[/URL] Your aromatization rate is over 0.8%, certainly on the high side. Most likely it's the hCG that's pushing it up. Excess emotionalism is a common symptom. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
E2: what is "high" and "low"
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