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I'm not saying E2 wouldn't rise to that level in some men as you stated- I'm saying that I personally feel like shit if my E2 gets above my SHBG, regardless of how high my testosterone is. I guess what I should have said is "I'm a big believer in E2 to SHBG ratio being the driving factor in how you feel" simply based on my own experience. Anecdotally though, I'm maintaining at close to 1050 total/22 free with my E2 and SHBG in the 25 range with very little AI these days, and this is where I feel the best.


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