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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
E2 and Testosterone Protect Against Bone Marrow Fat & Osteoporosis
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<blockquote data-quote="CoastWatcher" data-source="post: 93084" data-attributes="member: 2624"><p>Higher bone marrow fat (BMF) is associated with osteoporosis and reduced hematopoiesis. <em>Exogenous</em> <em>estradiol reduces BMF in older women, but effects of endogenous sex hormones are unknown.</em></p><p><em></em></p><ul> <li data-xf-list-type="ul">244 men and 226 women, mean age 81.5 (SD 4.1) years, all residents of Iceland were enrolled in this study.</li> <li data-xf-list-type="ul">Vertebral BMF was measured with magnetic resonance spectroscopy. Estradiol, testosterone and sex hormone binding globulin were measured on archived serum.</li> <li data-xf-list-type="ul">Mean BMF was 54.1% (SD 8.6) (men) and 54.7% (SD 8.1) (women).</li> <li data-xf-list-type="ul"> In adjusted models, per 1pg/ml increase in total estradiol, there was a statistically significant 0.26% decrease in BMF in men (95% CI: -0.41, -0.11) and a non-significant 0.20% decrease in women (95% CI: -0.55, 0.15), with no evidence of interaction by gender.</li> <li data-xf-list-type="ul">Per 10ng/dl increase in total testosterone, there was a significant 0.10% decrease in BMF in men (95% CI: -0.17, -0.03) and a non-significant 0.13% (95% CI: -0.79, 0.53) decrease in women, with no evidence of interaction by gender (p=0.97).</li> </ul><p></p><p>CONCLUSION: </p><p></p><p>Higher bone marrow fat is associated with lower total estradiol and testosterone levels in older men, with a similar but statistically non-significant association in older women. Sex hormone levels appear to play a role in the regulation of bone marrow fat in older adults.</p><p></p><p>"Sex hormones are negatively associated with vertebral bone marrow fat," <em>Bone, 2017 December 11, </em><a href="https://www.ncbi.nlm.nih.gov/pubmed/29241825/" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/29241825/</a></p></blockquote><p></p>
[QUOTE="CoastWatcher, post: 93084, member: 2624"] Higher bone marrow fat (BMF) is associated with osteoporosis and reduced hematopoiesis. [I]Exogenous[/I] [I]estradiol reduces BMF in older women, but effects of endogenous sex hormones are unknown. [/I] [LIST] [*]244 men and 226 women, mean age 81.5 (SD 4.1) years, all residents of Iceland were enrolled in this study. [*]Vertebral BMF was measured with magnetic resonance spectroscopy. Estradiol, testosterone and sex hormone binding globulin were measured on archived serum. [*]Mean BMF was 54.1% (SD 8.6) (men) and 54.7% (SD 8.1) (women). [*] In adjusted models, per 1pg/ml increase in total estradiol, there was a statistically significant 0.26% decrease in BMF in men (95% CI: -0.41, -0.11) and a non-significant 0.20% decrease in women (95% CI: -0.55, 0.15), with no evidence of interaction by gender. [*]Per 10ng/dl increase in total testosterone, there was a significant 0.10% decrease in BMF in men (95% CI: -0.17, -0.03) and a non-significant 0.13% (95% CI: -0.79, 0.53) decrease in women, with no evidence of interaction by gender (p=0.97). [/LIST] CONCLUSION: Higher bone marrow fat is associated with lower total estradiol and testosterone levels in older men, with a similar but statistically non-significant association in older women. Sex hormone levels appear to play a role in the regulation of bone marrow fat in older adults. "Sex hormones are negatively associated with vertebral bone marrow fat," [I]Bone, 2017 December 11, [/I][URL]https://www.ncbi.nlm.nih.gov/pubmed/29241825/[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
E2 and Testosterone Protect Against Bone Marrow Fat & Osteoporosis
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