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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Dr Saya Presents a Case Study for Possible Upper Limit of Physiologic Estradiol Levels in a Male
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<blockquote data-quote="lowtest" data-source="post: 39970" data-attributes="member: 13329"><p>Wow that was an interesting reply. I love the science behind hormones, and love thinking about different mechanisms that allow the endocrine system to function in my free time.</p><p></p><p>What you're describing sounds almost like a biphasic effect of estradiol in the feedback loop. I think that makes sense, as a layman of course. What about the possibility of down-regulation of estrogen receptors. possibly on the hypothalamus or pituitary? Less receptors, less effect = the body producing more testosterone in order to increase estradiol? From what I understand, testosterone itself also provides some of the negative feedback in the HPTA for men as well, I'm assuming that estradiol has a stronger effect than testosterone, right?</p><p></p><p>You're right this is incredibly interesting. I of course understand that you wouldn't support treating a low t and e male patient with estradiol. </p><p></p><p>If possible, how would you treat a male patient with normal testosterone(or low normal) and very low estradiol? Obviously if you can't give estradiol, the only way to fix that is testosterone? Keep in mind I am NOT taking this a diagnosis, or treatment, merely taking it as information.</p><p></p><p>I am considering using defy, but I am concerned that I will be told again that I can't be treated due to my levels being too high. 400-500 ng/dl total testosterone, but low estradiol. All of the doctors I have seen have told me they can't treat me due to my young age(25), and I don't want to waste anymore time or money in having doctors tell me they can't help. I am frustrated you know?</p></blockquote><p></p>
[QUOTE="lowtest, post: 39970, member: 13329"] Wow that was an interesting reply. I love the science behind hormones, and love thinking about different mechanisms that allow the endocrine system to function in my free time. What you're describing sounds almost like a biphasic effect of estradiol in the feedback loop. I think that makes sense, as a layman of course. What about the possibility of down-regulation of estrogen receptors. possibly on the hypothalamus or pituitary? Less receptors, less effect = the body producing more testosterone in order to increase estradiol? From what I understand, testosterone itself also provides some of the negative feedback in the HPTA for men as well, I'm assuming that estradiol has a stronger effect than testosterone, right? You're right this is incredibly interesting. I of course understand that you wouldn't support treating a low t and e male patient with estradiol. If possible, how would you treat a male patient with normal testosterone(or low normal) and very low estradiol? Obviously if you can't give estradiol, the only way to fix that is testosterone? Keep in mind I am NOT taking this a diagnosis, or treatment, merely taking it as information. I am considering using defy, but I am concerned that I will be told again that I can't be treated due to my levels being too high. 400-500 ng/dl total testosterone, but low estradiol. All of the doctors I have seen have told me they can't treat me due to my young age(25), and I don't want to waste anymore time or money in having doctors tell me they can't help. I am frustrated you know? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Dr Saya Presents a Case Study for Possible Upper Limit of Physiologic Estradiol Levels in a Male
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