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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Dr Saya Presents a Case Study for Possible Upper Limit of Physiologic Estradiol Levels in a Male
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<blockquote data-quote="Nelson Vergel" data-source="post: 39830" data-attributes="member: 3"><p>Good article, Dr Saya. Very informative for men whose HPTA is not already suppressed. It reinforces the upper limit of E2 in men wit endogeneous testosterone production. But for men on TRT with fully suppressed HPTA, this information may not be applicable since they have artificially high T and no concerns about HPTA suppression since that is a given with TRT.</p><p></p><p>We know that in a healthy male about .3 % of T converts to E2. This means that E2 will go up as T increases. Nature and evolution have ensured that we have enough E2 to balance T. Why disrupt this balance with anastrozole unless the conversion is much above .3% due to liver, fat, or medication effects on aromatization?</p><p></p><p>We have very few data on T/E2 ratios and how they correlate to fertility, the best endpoint for proper HPTA function. Do we really need to improve a T/E2 ratio that is already over 14 with the use of anastrozole? I have not found a study that looks into that yet.</p><p></p><p></p><p><a href="https://www.excelmale.com/forum/showthread.php?4921-Is-Testosterone-to-Estradiol-Ratio-Important-in-Men" target="_blank">https://www.excelmale.com/forum/showthread.php?4921-Is-Testosterone-to-Estradiol-Ratio-Important-in-Men</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 39830, member: 3"] Good article, Dr Saya. Very informative for men whose HPTA is not already suppressed. It reinforces the upper limit of E2 in men wit endogeneous testosterone production. But for men on TRT with fully suppressed HPTA, this information may not be applicable since they have artificially high T and no concerns about HPTA suppression since that is a given with TRT. We know that in a healthy male about .3 % of T converts to E2. This means that E2 will go up as T increases. Nature and evolution have ensured that we have enough E2 to balance T. Why disrupt this balance with anastrozole unless the conversion is much above .3% due to liver, fat, or medication effects on aromatization? We have very few data on T/E2 ratios and how they correlate to fertility, the best endpoint for proper HPTA function. Do we really need to improve a T/E2 ratio that is already over 14 with the use of anastrozole? I have not found a study that looks into that yet. [URL]https://www.excelmale.com/forum/showthread.php?4921-Is-Testosterone-to-Estradiol-Ratio-Important-in-Men[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Dr Saya Presents a Case Study for Possible Upper Limit of Physiologic Estradiol Levels in a Male
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