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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Down-titration helped reduce E2 a bit, but it isn't enough. Time for an AI?
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<blockquote data-quote="Cataceous" data-source="post: 221275" data-attributes="member: 38109"><p>Your aromatization rate is nothing unusual, 0.55%, within a normal range of roughly 0.3-0.6%. Your dosing is high; you're taking more than double the testosterone the average healthy young guy makes naturally. You should disregard Labcorp's direct free testosterone results; they are too inaccurate to trust. Even the calculators are better. In other words, it's highly unlikely your free testosterone was cut in half by a minor 16% dose reduction. Furthermore, your original numbers do not necessarily reflect hypogonadism; Vermeulen calculated free testosterone is in the healthy normal range, while Tru-T is borderline. A test of free testosterone via equilibrium dialysis would help to resolve the issue.</p><p></p><p>There's a reasonable chance your SHBG has dropped further since you started TRT; androgens tend to reduce production. Low SHBG artificially lowers total testosterone, so total testosterone can appear normal even when free testosterone is elevated. Or it can appear low even when free testosterone is normal. It's better to focus on free testosterone if it can be determined accurately.</p><p></p><p>My first suggestion is to abandon conventional TRT and try Natesto or enclomiphene instead. Otherwise a further dose reduction makes sense, while continuing to inject daily. Physiological dosing is usually achieved with 50-100 mg of testosterone cypionate per week, so you have plenty of leeway before you're in danger of being low. These suggestions are made with the assumption that your priorities are long-term good health and a minimization of side effects.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 221275, member: 38109"] Your aromatization rate is nothing unusual, 0.55%, within a normal range of roughly 0.3-0.6%. Your dosing is high; you're taking more than double the testosterone the average healthy young guy makes naturally. You should disregard Labcorp's direct free testosterone results; they are too inaccurate to trust. Even the calculators are better. In other words, it's highly unlikely your free testosterone was cut in half by a minor 16% dose reduction. Furthermore, your original numbers do not necessarily reflect hypogonadism; Vermeulen calculated free testosterone is in the healthy normal range, while Tru-T is borderline. A test of free testosterone via equilibrium dialysis would help to resolve the issue. There's a reasonable chance your SHBG has dropped further since you started TRT; androgens tend to reduce production. Low SHBG artificially lowers total testosterone, so total testosterone can appear normal even when free testosterone is elevated. Or it can appear low even when free testosterone is normal. It's better to focus on free testosterone if it can be determined accurately. My first suggestion is to abandon conventional TRT and try Natesto or enclomiphene instead. Otherwise a further dose reduction makes sense, while continuing to inject daily. Physiological dosing is usually achieved with 50-100 mg of testosterone cypionate per week, so you have plenty of leeway before you're in danger of being low. These suggestions are made with the assumption that your priorities are long-term good health and a minimization of side effects. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Down-titration helped reduce E2 a bit, but it isn't enough. Time for an AI?
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