ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Does TRT reverse/improve sexual symptoms for most men with High Range SHBG / Lower Free T?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Cataceous" data-source="post: 223579" data-attributes="member: 38109"><p>Short answer: SHBG-bound testosterone eventually gets released at random. The body does not just discard the complex. Long answer: At the molecular, level associations and dissociations occur randomly. But with the huge numbers involved statistics can be used to make predictions about the relative numbers of bound and unbound molecules. The binding of SHBG with testosterone is particularly complex due to allostery.</p><p></p><p>I've previously used this analogy to equate the process to something relatable: You have a large number of energetic monkeys in a room. They're all running around bumping into each other. Now imagine that the monkeys are wearing vests with Velcro on the outside. Some have the hook side and the rest have the loop side. As the monkeys run around and bump into one another sometimes one with hooks will stick to one with loops. They continue squirming and jumping around together until they break apart. Your variables include the concentrations of the two types of monkeys, their energies, and the stickiness of the Velcro. The latter corresponds to the binding affinities of molecules—the stronger the binding force the longer on average it takes for dissociation to occur after association.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 223579, member: 38109"] Short answer: SHBG-bound testosterone eventually gets released at random. The body does not just discard the complex. Long answer: At the molecular, level associations and dissociations occur randomly. But with the huge numbers involved statistics can be used to make predictions about the relative numbers of bound and unbound molecules. The binding of SHBG with testosterone is particularly complex due to allostery. I've previously used this analogy to equate the process to something relatable: You have a large number of energetic monkeys in a room. They're all running around bumping into each other. Now imagine that the monkeys are wearing vests with Velcro on the outside. Some have the hook side and the rest have the loop side. As the monkeys run around and bump into one another sometimes one with hooks will stick to one with loops. They continue squirming and jumping around together until they break apart. Your variables include the concentrations of the two types of monkeys, their energies, and the stickiness of the Velcro. The latter corresponds to the binding affinities of molecules—the stronger the binding force the longer on average it takes for dissociation to occur after association. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Does TRT reverse/improve sexual symptoms for most men with High Range SHBG / Lower Free T?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top