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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Does TRT reverse/improve sexual symptoms for most men with High Range SHBG / Lower Free T?
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<blockquote data-quote="tareload" data-source="post: 223551"><p>Fun to read again (at least for rodents):</p><p></p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066276/[/URL]</p><p>[ATTACH=full]21699[/ATTACH]</p><p></p><p><em>In summary, our detailed examination of the SHBG-Tg model reveals that contrary to the general misconception that SHBG decreases free T concentrations, in vivo it mainly increases total androgen and estrogen concentrations (via hypothalamic-pituitary feedback and prolonged circulating half-life). Nevertheless, SHBG attenuated androgen bioactivity resulting in mild hypogonadal signs in reproductive organs, but no major phenotypic effects on other sexually dimorphic target tissues. These findings offer empirical support for measuring free or bioavailable T in clinical practice, since SHBG can clearly confound interpretations based on circulating total sex steroid concentrations. Although we found no evidence that SHBG has ligand-independent effects in vivo, alternative mechanisms of action beyond the regulation of sex steroid plasma transport may still contribute to effects on certain organs<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066276/#b9" target="_blank">9</a>,<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066276/#b10" target="_blank">10</a>. Finally, our study may assist in the appropriate use of male mouse models for translational biomedical research.</em></p><p></p><p>And some additional commentary that gets me thinking about the rodent studies WRT testosterone toxicity:</p><p>[ATTACH=full]21700[/ATTACH]</p><p>[USER=18514]@DS3[/USER]</p><p></p><p>Fun to hypothesize how these data affect the discussion we had on high testosterone in rodents vs males and the toxicity curves. Obviously there is only so much SHBG can do to tie up fT so again it remains to be determined if rodent hearts are more sensitive to fT than humans. FYI.</p></blockquote><p></p>
[QUOTE="tareload, post: 223551"] Fun to read again (at least for rodents): [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066276/[/URL] [ATTACH type="full" alt="1652199871716.png"]21699[/ATTACH] [I]In summary, our detailed examination of the SHBG-Tg model reveals that contrary to the general misconception that SHBG decreases free T concentrations, in vivo it mainly increases total androgen and estrogen concentrations (via hypothalamic-pituitary feedback and prolonged circulating half-life). Nevertheless, SHBG attenuated androgen bioactivity resulting in mild hypogonadal signs in reproductive organs, but no major phenotypic effects on other sexually dimorphic target tissues. These findings offer empirical support for measuring free or bioavailable T in clinical practice, since SHBG can clearly confound interpretations based on circulating total sex steroid concentrations. Although we found no evidence that SHBG has ligand-independent effects in vivo, alternative mechanisms of action beyond the regulation of sex steroid plasma transport may still contribute to effects on certain organs[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066276/#b9']9[/URL],[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066276/#b10']10[/URL]. Finally, our study may assist in the appropriate use of male mouse models for translational biomedical research.[/I] And some additional commentary that gets me thinking about the rodent studies WRT testosterone toxicity: [ATTACH type="full" alt="1652200039032.png"]21700[/ATTACH] [USER=18514]@DS3[/USER] Fun to hypothesize how these data affect the discussion we had on high testosterone in rodents vs males and the toxicity curves. Obviously there is only so much SHBG can do to tie up fT so again it remains to be determined if rodent hearts are more sensitive to fT than humans. FYI. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Does TRT reverse/improve sexual symptoms for most men with High Range SHBG / Lower Free T?
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