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Does TRT increase tendonitis?
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<blockquote data-quote="FunkOdyssey" data-source="post: 263056" data-attributes="member: 44064"><p>The presence of the medications is a confounding variable here. To eliminate that, you would need to elevate your E2 to the same range without enclomiphene and hCG and observe effects on tendonitis. It is possible, for example, that tendonitis is a side effect of enclomiphene, either through its estrogen receptor antagonism (inducing a local state of "low E2"), by its well-documented reduction of IGF-1 level, or some other mechanism.</p><p></p><p>The review below explores the links between estrogen and tendon health and the balance of evidence presented suggests estrogen is protective of tendons and deficiency is detrimental in various ways. They note that high levels of estrogen are apparently detrimental to tendon health only in young women, where the opposite is true in older women. Postmenopausal women have more tendon pathology than premenopausal women and this change is attributed to estrogen deficiency.</p><p></p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241423/[/URL]</p><p></p><p>Some discussion of related complaints from enclomiphene users:</p><p></p><p>[MEDIA=reddit]sarmssourcetalk/comments/py0zc8[/MEDIA]</p><p>[MEDIA=reddit]sarmssourcetalk/comments/wvttug[/MEDIA]</p><p>[MEDIA=reddit]Testosterone/comments/12ibxkv[/MEDIA]</p></blockquote><p></p>
[QUOTE="FunkOdyssey, post: 263056, member: 44064"] The presence of the medications is a confounding variable here. To eliminate that, you would need to elevate your E2 to the same range without enclomiphene and hCG and observe effects on tendonitis. It is possible, for example, that tendonitis is a side effect of enclomiphene, either through its estrogen receptor antagonism (inducing a local state of "low E2"), by its well-documented reduction of IGF-1 level, or some other mechanism. The review below explores the links between estrogen and tendon health and the balance of evidence presented suggests estrogen is protective of tendons and deficiency is detrimental in various ways. They note that high levels of estrogen are apparently detrimental to tendon health only in young women, where the opposite is true in older women. Postmenopausal women have more tendon pathology than premenopausal women and this change is attributed to estrogen deficiency. [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241423/[/URL] Some discussion of related complaints from enclomiphene users: [MEDIA=reddit]sarmssourcetalk/comments/py0zc8[/MEDIA] [MEDIA=reddit]sarmssourcetalk/comments/wvttug[/MEDIA] [MEDIA=reddit]Testosterone/comments/12ibxkv[/MEDIA] [/QUOTE]
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Does TRT increase tendonitis?
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