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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Does Testosterone Replacement Affect the Thyroid?
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<blockquote data-quote="Nelson Vergel" data-source="post: 19076" data-attributes="member: 3"><p>1- One study showed that the use of an androgen that does not get converted to estradiol affects the way the thyroid gland responds to thyroid releasing hormone (TRH):</p><p></p><p>"Fluoxymesterone, an androgen not converted to estrogen, caused a significant decrease in the TSH response to TRH in 11 men with primary hypogonadism [maximum change in TSH: before treatment, 11.3 ° 0.9 juU/ml (mean ° SE); 8.9 ° 1.0 after 2 weeks (P < 0.001); 8.2 ° 1.1 after6 weeks (P < 0.01)]. There was a significant fall in serum Thyroxine−binding globulin (TBG) (measured directly by RIA) without a change in the free T4 or free T3 index.</p><p><a href="http://press.endocrine.org/doi/abs/10.1210/jcem-52-2-173" target="_blank">http://press.endocrine.org/doi/abs/10.1210/jcem-52-2-173</a></p><p></p><p></p><p>2- Another study looked at the effect of hCG (which raises T and E2):</p><p></p><p> After 3 months of hCG treatment, there was a marked rise in serum estradiol as well as testosterone. Serum T4 was reduced without a change in T3, T3 resin uptake, or TBG. Furthermore, there was no alteration in the TSH response to TRH.</p><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/6408116" target="_blank">The thyrotropin (TSH) profile in isolated gonadotropin deficiency: a model to evaluate the effect of sex steroids on TSH secretion - PubMed</a></p><p></p><p>3- This next study showed the effect of anabolic steroids on thyroid function. However, it does not mention if the were aromatizing anabolics or not. My opinion is that estradiol has a normalizing effect on thyroid function. Low E2 may be the cause for these results:</p><p></p><p>During the use of steroids significant decreases (P < 0.05 to 0.001) in the serum concentrations of thyroid stimulating hormone, thyroxine, triidothyronine, free thyroxine, and thyroid hormone-binding globulin (TBG) were found, whereas the value of triidothyronine uptake increased (P < 0.001). In relation to the changes in the thyroid function parameters measured, we suggest that the primary target of androgen action was TBG biosynthesis.</p><p></p><p><a href="http://ajs.sagepub.com/content/15/4/357.short" target="_blank">http://ajs.sagepub.com/content/15/4/357.short</a></p><p></p><p></p><p>4- This other study shows that increasing testosterone (using hCG in this case) can increase the conversion of T4 to T3 by reducing Thyroxine-binding globulin (TBG). I bet this is one of the reasons people lose fat and may also feel "hot" on TRT.</p><p></p><p>[URL unfurl="true"]https://www.endocrine-abstracts.org/ea/0084/ea0084ps1-05-44[/URL]</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 19076, member: 3"] 1- One study showed that the use of an androgen that does not get converted to estradiol affects the way the thyroid gland responds to thyroid releasing hormone (TRH): "Fluoxymesterone, an androgen not converted to estrogen, caused a significant decrease in the TSH response to TRH in 11 men with primary hypogonadism [maximum change in TSH: before treatment, 11.3 ° 0.9 juU/ml (mean ° SE); 8.9 ° 1.0 after 2 weeks (P < 0.001); 8.2 ° 1.1 after6 weeks (P < 0.01)]. There was a significant fall in serum Thyroxine−binding globulin (TBG) (measured directly by RIA) without a change in the free T4 or free T3 index. [URL]http://press.endocrine.org/doi/abs/10.1210/jcem-52-2-173[/URL] 2- Another study looked at the effect of hCG (which raises T and E2): After 3 months of hCG treatment, there was a marked rise in serum estradiol as well as testosterone. Serum T4 was reduced without a change in T3, T3 resin uptake, or TBG. Furthermore, there was no alteration in the TSH response to TRH. [URL='http://www.ncbi.nlm.nih.gov/pubmed/6408116']The thyrotropin (TSH) profile in isolated gonadotropin deficiency: a model to evaluate the effect of sex steroids on TSH secretion - PubMed[/URL] 3- This next study showed the effect of anabolic steroids on thyroid function. However, it does not mention if the were aromatizing anabolics or not. My opinion is that estradiol has a normalizing effect on thyroid function. Low E2 may be the cause for these results: During the use of steroids significant decreases (P < 0.05 to 0.001) in the serum concentrations of thyroid stimulating hormone, thyroxine, triidothyronine, free thyroxine, and thyroid hormone-binding globulin (TBG) were found, whereas the value of triidothyronine uptake increased (P < 0.001). In relation to the changes in the thyroid function parameters measured, we suggest that the primary target of androgen action was TBG biosynthesis. [URL]http://ajs.sagepub.com/content/15/4/357.short[/URL] 4- This other study shows that increasing testosterone (using hCG in this case) can increase the conversion of T4 to T3 by reducing Thyroxine-binding globulin (TBG). I bet this is one of the reasons people lose fat and may also feel "hot" on TRT. [URL unfurl="true"]https://www.endocrine-abstracts.org/ea/0084/ea0084ps1-05-44[/URL] [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Does Testosterone Replacement Affect the Thyroid?
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