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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Does Testosterone Replacement Affect the Thyroid?
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<blockquote data-quote="Nelson Vergel" data-source="post: 124162" data-attributes="member: 3"><p>From the Labcorp site (info on thyroid binding globulin)</p><p></p><p>"TBG is increased by estrogens, tamoxifen, pregnancy, perphenazine, and in some cases of liver disease, including hepatitis. Decreased TBG is found with some instances of chronic liver disease, nephrosis and systemic disease, and with large amounts of glucocorticoids, <strong>androgens</strong>/anabolic steroids, and acromegaly. "</p><p></p><p>I think the effect of testosterone doses under 150 mg per week should not considerably lower TBG</p><p></p><p>This study in female to male transgenders using a high T dose of 500 mg per week corroborated that statement:</p><p></p><p></p><p>Eur J Endocrinol. 2006 Jul;155(1):11-6.</p><p></p><p><strong>The effects of sex-steroid administration on the pituitary-thyroid axis in transsexuals.</strong></p><p>Bisschop PH1, Toorians AW, Endert E, Wiersinga WM, Gooren LJ, Fliers E.</p><p></p><p></p><p>Abstract</p><p>OBJECTIVE:</p><p>Estrogen and androgen administration modulate the pituitary-thyroid axis through alterations in thyroid hormone-binding globulin (TBG) metabolism, but the effects of sex steroids on extrathyroidal thyroxine (T4) to triiodothyronine (T3) conversion in humans are unknown.</p><p></p><p>DESIGN AND METHODS:</p><p>We studied 36 male-to-female and 14 female-to-male euthyroid transsexuals at baseline and after 4 months of hormonal treatment. Male-to-female transsexuals were treated with cyproterone acetate (CA) 100 mg/day alone (n = 10) or in combination with either oral ethinyl estradiol (or-EE) 100 microg/day (n = 14) or transdermal 17beta-estradiol (td-E) 100 microg twice a week (n = 12). <strong>Female-to-male transsexuals were treated with i.m. testosterone 250 mg twice a week</strong>. A t-test was used to test for differences within groups and ANOVA with post hoc analysis to test for differences between the groups.</p><p></p><p>RESULTS:</p><p>Or-EE increased TBG (100 +/- 12%, P < .001) and testosterone decreased TBG (-14 +/- 4%, P = 0.01), but free T4 did not change. Td-E and CA did not affect TBG concentrations. TSH was not different between groups at baseline or after treatment. CA decreased T3/T4 ratios (-9 +/- 3%, P = 0.04), suggesting that T4 to T3 conversion was lower. Testosterone increased T3/T4 ratios (30 +/- 9%, P = 0.02), which probably reflects higher T4 to T3 conversion.</p><p></p><p>CONCLUSION:</p><p>Oral but not transdermal estradiol increases TBG, <strong>whereas testosterone lowers TBG. Testosterone increases T3/T4 ratios.</strong> Estradiol does not affect T3/T4 ratios, irrespective of the route of administration.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 124162, member: 3"] From the Labcorp site (info on thyroid binding globulin) "TBG is increased by estrogens, tamoxifen, pregnancy, perphenazine, and in some cases of liver disease, including hepatitis. Decreased TBG is found with some instances of chronic liver disease, nephrosis and systemic disease, and with large amounts of glucocorticoids, [B]androgens[/B]/anabolic steroids, and acromegaly. " I think the effect of testosterone doses under 150 mg per week should not considerably lower TBG This study in female to male transgenders using a high T dose of 500 mg per week corroborated that statement: Eur J Endocrinol. 2006 Jul;155(1):11-6. [B]The effects of sex-steroid administration on the pituitary-thyroid axis in transsexuals.[/B] Bisschop PH1, Toorians AW, Endert E, Wiersinga WM, Gooren LJ, Fliers E. Abstract OBJECTIVE: Estrogen and androgen administration modulate the pituitary-thyroid axis through alterations in thyroid hormone-binding globulin (TBG) metabolism, but the effects of sex steroids on extrathyroidal thyroxine (T4) to triiodothyronine (T3) conversion in humans are unknown. DESIGN AND METHODS: We studied 36 male-to-female and 14 female-to-male euthyroid transsexuals at baseline and after 4 months of hormonal treatment. Male-to-female transsexuals were treated with cyproterone acetate (CA) 100 mg/day alone (n = 10) or in combination with either oral ethinyl estradiol (or-EE) 100 microg/day (n = 14) or transdermal 17beta-estradiol (td-E) 100 microg twice a week (n = 12). [B]Female-to-male transsexuals were treated with i.m. testosterone 250 mg twice a week[/B]. A t-test was used to test for differences within groups and ANOVA with post hoc analysis to test for differences between the groups. RESULTS: Or-EE increased TBG (100 +/- 12%, P < .001) and testosterone decreased TBG (-14 +/- 4%, P = 0.01), but free T4 did not change. Td-E and CA did not affect TBG concentrations. TSH was not different between groups at baseline or after treatment. CA decreased T3/T4 ratios (-9 +/- 3%, P = 0.04), suggesting that T4 to T3 conversion was lower. Testosterone increased T3/T4 ratios (30 +/- 9%, P = 0.02), which probably reflects higher T4 to T3 conversion. CONCLUSION: Oral but not transdermal estradiol increases TBG, [B]whereas testosterone lowers TBG. Testosterone increases T3/T4 ratios.[/B] Estradiol does not affect T3/T4 ratios, irrespective of the route of administration. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Does Testosterone Replacement Affect the Thyroid?
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