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I used to have a LOT of muscle cramps nearly every day, then 10 years ago I discovered supplementing with magnesium would stop me from having cramps.  This is with or without TRT.


So I pay a lot of attention to magnesium, one supplement I take is Magtein magnesium l-threonate, this is the only form of magnesium that crosses the blood brain barrier.   Another I take is magnesium citrate, about 1700 mgs.


I recently tested my serum level of magnesium, it was near the top at 2.1 mg/dL (1.6-2.3), if I skip taking MG for a couple of days, I can start to feel it.  I don't normally check MG levels since I am physically sensitive to a lack of MG, but I needed to do the blood work for Defy, so picked a panel that also had MG serum.



Here what is interesting, despite all the MG I take, I would still get muscle cramps from doing a couple of sets of 50 ab crunches.  I had thought maybe I had poor circulation, I didn't think it had anything to do with MG, either cellular or serum.


The last few months I have been taking 6mg Boron, now no cramps during ab crunches at all.  Very surprised as I did not expect that.


I then read,  "Boron supplementation can affect biological half-life and bioavailability of E2 and vitamin D. significantly improves magnesium absorption and deposition in bone".


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712861/


So if anyone has trouble with magnesium, I would keep supplementing MG and add 6mg boron, maybe test your MG RBC levels a couple of months after starting the boron/MG combo.


If anyone does that and it works, it would be useful to report the results.


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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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