I used to have a LOT of muscle cramps nearly every day, then 10 years ago I discovered supplementing with magnesium would stop me from having cramps. This is with or without TRT.
So I pay a lot of attention to magnesium, one supplement I take is Magtein magnesium l-threonate, this is the only form of magnesium that crosses the blood brain barrier. Another I take is magnesium citrate, about 1700 mgs.
I recently tested my serum level of magnesium, it was near the top at 2.1 mg/dL (1.6-2.3), if I skip taking MG for a couple of days, I can start to feel it. I don't normally check MG levels since I am physically sensitive to a lack of MG, but I needed to do the blood work for Defy, so picked a panel that also had MG serum.
Here what is interesting, despite all the MG I take, I would still get muscle cramps from doing a couple of sets of 50 ab crunches. I had thought maybe I had poor circulation, I didn't think it had anything to do with MG, either cellular or serum.
The last few months I have been taking 6mg Boron, now no cramps during ab crunches at all. Very surprised as I did not expect that.
I then read, "Boron supplementation can affect biological half-life and bioavailability of E2 and vitamin D. significantly improves magnesium absorption and deposition in bone".
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712861/
So if anyone has trouble with magnesium, I would keep supplementing MG and add 6mg boron, maybe test your MG RBC levels a couple of months after starting the boron/MG combo.
If anyone does that and it works, it would be useful to report the results.
