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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Does Testosterone Promote Colorectal Cancer?
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<blockquote data-quote="CoastWatcher" data-source="post: 89185" data-attributes="member: 2624"><p>It may. </p><p></p><p>Colorectal cancer (CRC) is the fourth commonest type of malignancy after breast, lung and prostate in the USA and accounts for approximately 49,190 deaths annually in USA alone. The 5-year survival rate of CRC has increased over the past decades, in part, due to greater awareness and the widespread implementation of national screening programmes. Recently, a number of studies reported that males have a higher risk of developing CRC due to the action of testosterone.</p><p></p><ul> <li data-xf-list-type="ul">Studies on rats with mutated <em>Apc</em> tumour-suppressor gene subjected to either ovariectomy or orchidectomy exhibit different risks of CRC.</li> <li data-xf-list-type="ul">Female rats subjected to ovariectomy are at higher risk of CRC, whereas orchidectomised male rats exhibit a lower risk of developing CRC.</li> <li data-xf-list-type="ul">Sex hormones, in particular estrogen and testosterone, play a significant role in the development of CRC since the anti-neoplastic effect of estrogen lost during ovariectomy increases the risk of females developing CRC.</li> <li data-xf-list-type="ul">Testosterone similarly plays important roles in human CRC.</li> <li data-xf-list-type="ul">Long cytosine-adenine-guanine (CAG) repeats in the gene for the androgen receptors have been associated with a poor 5-year survival compared to shorter CAG repeats.</li> <li data-xf-list-type="ul"> Very recently, the measurement of serum unbound testosterone has been suggested as a novel biomarker along with carcinoembryonic antigen in CRC. In conclusion, testosterone may promote the development of CRC via a number of pathways, which may place males at greater risk.</li> </ul><p></p><p>Testosterone holds promise as a potential biomarker in CRC risk prediction; however, further studies are required to better define its role in colorectal neoplasia.</p><p></p><p>"The role of testosterone in colorectal carcinoma: pathomechanisms and open questions," <em>EPMA Journal, </em>2016 November 10, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103431/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103431/</a></p></blockquote><p></p>
[QUOTE="CoastWatcher, post: 89185, member: 2624"] It may. Colorectal cancer (CRC) is the fourth commonest type of malignancy after breast, lung and prostate in the USA and accounts for approximately 49,190 deaths annually in USA alone. The 5-year survival rate of CRC has increased over the past decades, in part, due to greater awareness and the widespread implementation of national screening programmes. Recently, a number of studies reported that males have a higher risk of developing CRC due to the action of testosterone. [LIST] [*]Studies on rats with mutated [I]Apc[/I] tumour-suppressor gene subjected to either ovariectomy or orchidectomy exhibit different risks of CRC. [*]Female rats subjected to ovariectomy are at higher risk of CRC, whereas orchidectomised male rats exhibit a lower risk of developing CRC. [*]Sex hormones, in particular estrogen and testosterone, play a significant role in the development of CRC since the anti-neoplastic effect of estrogen lost during ovariectomy increases the risk of females developing CRC. [*]Testosterone similarly plays important roles in human CRC. [*]Long cytosine-adenine-guanine (CAG) repeats in the gene for the androgen receptors have been associated with a poor 5-year survival compared to shorter CAG repeats. [*] Very recently, the measurement of serum unbound testosterone has been suggested as a novel biomarker along with carcinoembryonic antigen in CRC. In conclusion, testosterone may promote the development of CRC via a number of pathways, which may place males at greater risk. [/LIST] Testosterone holds promise as a potential biomarker in CRC risk prediction; however, further studies are required to better define its role in colorectal neoplasia. "The role of testosterone in colorectal carcinoma: pathomechanisms and open questions," [I]EPMA Journal, [/I]2016 November 10, [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103431/[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Does Testosterone Promote Colorectal Cancer?
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