ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Does Testosterone Increase the Chance for a Heart Attack?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Nelson Vergel" data-source="post: 144201" data-attributes="member: 3"><p style="margin-left: 20px"></p> <p style="margin-left: 20px"><img src="https://www.excelmale.com/attachment.php?attachmentid=1070&d=1412803232" class="bbImage" alt="" data-url="https://www.excelmale.com/attachment.php?attachmentid=1070&d=1412803232" style="" /></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">“Many healthcare providers hesitate to initiate men on testosterone replacement therapy (TRT) due to the belief that these treatments increase the risk of cardiovascular (CV) events. However, the data supporting this belief are conflicting. A systematic review and meta-analysis of 30 randomized trials assessed the effect of TRT on CV events and risk factors in 1642 men with different degrees of androgen deficiency – 808 were on TRT. The results were inconsistent across trials, but did not support an association between testosterone use and important CV effects. In another systematic review and meta-analysis of 51 randomized trials, the relative risks of myocardial infarction, arrhythmia, coronary bypass surgery and all- cause mortality were not significantly increased with TRT use.</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">The Testosterone in Older Men with Mobility Limitations (TOM) trial randomly assigned 209 men with mobility issues and low testosterone to 6 months’ treatment with testosterone gel to improve lower extremity strength and physical function.</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">In this population of older men with limitations in mobility and a high prevalence of chronic disease, testosterone gel was associated with an increased risk of CV events. However, these results should be interpreted with caution, as the study was not designed to assess CV disease, and more patients in the testosterone arm had hypertension or dyslipidemia at baseline. Moreover, the prescribed dose of testosterone was two times the standard starting dose and the criteria for CV events were relatively subjective and non-specific, including for example the complaint of shortness of breath, tachycardia or leg edema. The small size of the trial and the unique population should limit physicians from making broader assumptions about the safety of TRT for other patient populations.</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">More recently, a retrospective study of 8709 hypogonadal men who underwent coronary angiography in the Veterans Affairs system between 2005 and 2011 assessed the association between testosterone therapy and all-cause mortality, myocardial infarction (MI) or stroke<em>.</em> Overall, the unadjusted data demonstrated a protective effect of TRT use on CV risk; however, the adjusted data showed an adverse impact. Puzzling, however, is that the testosterone levels among the men on TRT versus men not on TRT were unknown. The testosterone levels among the men experiencing a CV event versus men without an event were unknown. Also concerning is that about 100 of the “men” in this study were later reported to be women.”</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">Source: Testosterone deficiency and replacement: Myths and Realities. <em>Can Urol Assoc J </em>2014;8(7-8):S145-7.</p> <p style="margin-left: 20px"></p><p></p><p>The post <a href="https://www.testosteronewisdom.com/2905/does-testosterone-increase-the-chance-for-a-heart-attack/" target="_blank">Does Testosterone Increase the Chance for a Heart Attack?</a> appeared first on <a href="https://www.testosteronewisdom.com" target="_blank">Testosterone Wisdom</a>.</p><p></p><p><a href="https://www.testosteronewisdom.com/2905/does-testosterone-increase-the-chance-for-a-heart-attack/" target="_blank">Continue reading...</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 144201, member: 3"] [INDENT] [IMG]https://www.excelmale.com/attachment.php?attachmentid=1070&d=1412803232[/IMG] “Many healthcare providers hesitate to initiate men on testosterone replacement therapy (TRT) due to the belief that these treatments increase the risk of cardiovascular (CV) events. However, the data supporting this belief are conflicting. A systematic review and meta-analysis of 30 randomized trials assessed the effect of TRT on CV events and risk factors in 1642 men with different degrees of androgen deficiency – 808 were on TRT. The results were inconsistent across trials, but did not support an association between testosterone use and important CV effects. In another systematic review and meta-analysis of 51 randomized trials, the relative risks of myocardial infarction, arrhythmia, coronary bypass surgery and all- cause mortality were not significantly increased with TRT use. The Testosterone in Older Men with Mobility Limitations (TOM) trial randomly assigned 209 men with mobility issues and low testosterone to 6 months’ treatment with testosterone gel to improve lower extremity strength and physical function. In this population of older men with limitations in mobility and a high prevalence of chronic disease, testosterone gel was associated with an increased risk of CV events. However, these results should be interpreted with caution, as the study was not designed to assess CV disease, and more patients in the testosterone arm had hypertension or dyslipidemia at baseline. Moreover, the prescribed dose of testosterone was two times the standard starting dose and the criteria for CV events were relatively subjective and non-specific, including for example the complaint of shortness of breath, tachycardia or leg edema. The small size of the trial and the unique population should limit physicians from making broader assumptions about the safety of TRT for other patient populations. More recently, a retrospective study of 8709 hypogonadal men who underwent coronary angiography in the Veterans Affairs system between 2005 and 2011 assessed the association between testosterone therapy and all-cause mortality, myocardial infarction (MI) or stroke[I].[/I] Overall, the unadjusted data demonstrated a protective effect of TRT use on CV risk; however, the adjusted data showed an adverse impact. Puzzling, however, is that the testosterone levels among the men on TRT versus men not on TRT were unknown. The testosterone levels among the men experiencing a CV event versus men without an event were unknown. Also concerning is that about 100 of the “men” in this study were later reported to be women.” Source: Testosterone deficiency and replacement: Myths and Realities. [I]Can Urol Assoc J [/I]2014;8(7-8):S145-7. [/INDENT] The post [URL='https://www.testosteronewisdom.com/2905/does-testosterone-increase-the-chance-for-a-heart-attack/']Does Testosterone Increase the Chance for a Heart Attack?[/URL] appeared first on [URL='https://www.testosteronewisdom.com']Testosterone Wisdom[/URL]. [url="https://www.testosteronewisdom.com/2905/does-testosterone-increase-the-chance-for-a-heart-attack/"]Continue reading...[/url] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Does Testosterone Increase the Chance for a Heart Attack?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top