Vince,
Thanks so much for posting this article. I am MTHFR positive and am currently on B vitamin therapy. I having lowered my homocysteine levels from > 15.0 to around 8.0 right now. I am still processing the studies in the article which indicate that this type of treatment may not help CV disease. (In one study it shows a 24% reduction in stroke risk). It also gives five reasons why the studies did not pick up the benefits. A lot of the patients had CKD (kidney disease) vs. my condition.
I am going to continue on my treatment plan since I feel MUCH better with sound B vitamin levels in my body. (With MTHRF, the body does not process B vitamins well without a methyl compound added to them). I take a B multivitamin orally and B12 sublingually.
