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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Does SHBG affect the apparent half-lives of testosterone esters?
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<blockquote data-quote="Cataceous" data-source="post: 139467" data-attributes="member: 38109"><p>Ok, I can see how this might be reconciled with what the basic model is saying. See if you agree: Some guys with SHBG around 50 nmol/L are injecting 100 mg of T cypionate weekly and have trough T values averaging 500 ng/dL. Another group of guys has SHBG more like 10 nmol/L and follows the same protocol, yet their average trough T value is 250 ng/dL. So the natural conclusion is that the low-SHBG guys have excreted "it all out rather quickly". And they have, relatively, because their excretion rate is double that of the higher SHBG guys.</p><p></p><p>But here's the part where I got tripped up: I was assuming the low-SHBG guys would have equal or higher peaks than the high-SHBG guys. But I don't think this is the case. It looks as though the serum testosterone curves are proportionally smaller the whole time. In this example the high-SHBG guys might peak at 1000 ng/dL while the low SHBG guys would peak at only 500 ng/dL. Thus the half lives remain the same.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 139467, member: 38109"] Ok, I can see how this might be reconciled with what the basic model is saying. See if you agree: Some guys with SHBG around 50 nmol/L are injecting 100 mg of T cypionate weekly and have trough T values averaging 500 ng/dL. Another group of guys has SHBG more like 10 nmol/L and follows the same protocol, yet their average trough T value is 250 ng/dL. So the natural conclusion is that the low-SHBG guys have excreted "it all out rather quickly". And they have, relatively, because their excretion rate is double that of the higher SHBG guys. But here's the part where I got tripped up: I was assuming the low-SHBG guys would have equal or higher peaks than the high-SHBG guys. But I don't think this is the case. It looks as though the serum testosterone curves are proportionally smaller the whole time. In this example the high-SHBG guys might peak at 1000 ng/dL while the low SHBG guys would peak at only 500 ng/dL. Thus the half lives remain the same. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Does SHBG affect the apparent half-lives of testosterone esters?
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