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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Does Patient-Applied TRT Pose Risk for Blood Pressure Elevation?
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<blockquote data-quote="Nelson Vergel" data-source="post: 238237" data-attributes="member: 3"><p>Wow. Very interesting paper. I never thought about the issue related to dosing time/circadian rhythm/ blood testing. Who are the authors?</p><p></p><p>I like this:</p><p></p><p>"<strong><em>The foregoing discussion regarding the circadian-rhythm-based treatment of adrenal insufficiency (Addison’s disease) seems of relevance to PA-TRT and raises several pertinent questions in need of answers. For example, would before bedtime, as opposed to the now recommended morning time, application of solution and gel formulations result in a closer simulation of the normative TT circadian rhythm and improved safety and efficacy of treatment, perhaps even in a reduced dose? </em></strong><em><strong>Would unequal dosing of the oral soft gel capsule <a href="https://www.excelmale.com/forum/threads/fda-approves-new-oral-testosterone-capsule-called-jatenzo.18173/" target="_blank">Jatenzo</a>® TRT, for example, a higher dose in the evening before bedtime and a lower dose in the morning upon arising from slumber, better simulate the normative T circadian rhythm of day-active young men and lead to improved therapeutic outcomes and reduced risk for BP elevation, HTN, and MACE? "</strong></em></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 238237, member: 3"] Wow. Very interesting paper. I never thought about the issue related to dosing time/circadian rhythm/ blood testing. Who are the authors? I like this: "[B][I]The foregoing discussion regarding the circadian-rhythm-based treatment of adrenal insufficiency (Addison’s disease) seems of relevance to PA-TRT and raises several pertinent questions in need of answers. For example, would before bedtime, as opposed to the now recommended morning time, application of solution and gel formulations result in a closer simulation of the normative TT circadian rhythm and improved safety and efficacy of treatment, perhaps even in a reduced dose? [/I][/B][I][B]Would unequal dosing of the oral soft gel capsule [URL='https://www.excelmale.com/forum/threads/fda-approves-new-oral-testosterone-capsule-called-jatenzo.18173/']Jatenzo[/URL]® TRT, for example, a higher dose in the evening before bedtime and a lower dose in the morning upon arising from slumber, better simulate the normative T circadian rhythm of day-active young men and lead to improved therapeutic outcomes and reduced risk for BP elevation, HTN, and MACE? "[/B][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Does Patient-Applied TRT Pose Risk for Blood Pressure Elevation?
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