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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Does Patient-Applied TRT Pose Risk for Blood Pressure Elevation?
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<blockquote data-quote="madman" data-source="post: 238236" data-attributes="member: 13851"><p><strong>Didactic Synopsis </strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>Major teaching points </strong></p><p></p><p><em><strong>• Total and free blood testosterone (TT, FT) concentrations are circadian rhythmic in young healthy males; concentrations are highest during nighttime sleep, elevated following awakening, and lowest midmorning to late evening</strong></em></p><p><em><strong></strong></em></p><p><em><strong>• In elderly and hypogonadal men, mean T and FT blood levels are significantly dampened and their circadian variation is markedly depressed or absent </strong></em></p><p><em><strong></strong></em></p><p><em><strong>• In the United States, 13 different testosterone replacement therapies (TRTs) have been FDA-approved to treat male hypogonadism; 10 are patient-administered (PA). Six PA-TRTs are gel or solution types applied to shoulders, abdomen, axillae, or nostrils, and the others are ingested, self-injected, affixed above the incisors as a buccal tablet or placed as a dermal patch</strong></em></p><p><em><strong></strong></em></p><p><em><strong>• While all PA-TRTs are capable of correcting T deficiency, only the Androderm® patch applied nightly at approximately 22:00 h additionally closely reinstates normal testosterone circadian rhythmicity</strong></em></p><p></p><p><strong><em> • Complications of TRTs are elevated blood pressure (BP) and hypertension. Further investigation is required to determine if these and other adverse effects, like altered lipids and hematocrit and risk of major acute cardiovascular events (MACE), result from the produced T nonphysiologic 24 h patterning</em></strong></p><p><strong><em></em></strong></p><p><strong><em>• Determination of the true risk of elevated BP per unique TRT requires 48 h ambulatory BP monitoring and the correct choice of outcome measures, that is, asleep systolic BP mean and amount of asleep systolic BP dipping, most indicative of risk for MACE</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 238236, member: 13851"] [B]Didactic Synopsis Major teaching points [/B] [I][B]• Total and free blood testosterone (TT, FT) concentrations are circadian rhythmic in young healthy males; concentrations are highest during nighttime sleep, elevated following awakening, and lowest midmorning to late evening • In elderly and hypogonadal men, mean T and FT blood levels are significantly dampened and their circadian variation is markedly depressed or absent • In the United States, 13 different testosterone replacement therapies (TRTs) have been FDA-approved to treat male hypogonadism; 10 are patient-administered (PA). Six PA-TRTs are gel or solution types applied to shoulders, abdomen, axillae, or nostrils, and the others are ingested, self-injected, affixed above the incisors as a buccal tablet or placed as a dermal patch • While all PA-TRTs are capable of correcting T deficiency, only the Androderm® patch applied nightly at approximately 22:00 h additionally closely reinstates normal testosterone circadian rhythmicity[/B][/I] [B][I] • Complications of TRTs are elevated blood pressure (BP) and hypertension. Further investigation is required to determine if these and other adverse effects, like altered lipids and hematocrit and risk of major acute cardiovascular events (MACE), result from the produced T nonphysiologic 24 h patterning • Determination of the true risk of elevated BP per unique TRT requires 48 h ambulatory BP monitoring and the correct choice of outcome measures, that is, asleep systolic BP mean and amount of asleep systolic BP dipping, most indicative of risk for MACE[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Does Patient-Applied TRT Pose Risk for Blood Pressure Elevation?
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