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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Does Patient-Applied TRT Pose Risk for Blood Pressure Elevation?
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<blockquote data-quote="madman" data-source="post: 238234" data-attributes="member: 13851"><p><strong>Figure 2 Serum TT concentration 24 h pattern (with dispersion indices) under steady-state pharmacological conditions of each of the six nonbiosimilar FDA-approved gel and solution PA-TRTs. </strong></p><p><strong></strong></p><p><strong>The horizontal axis of each graph shows the time in hours after the previous dose.</strong></p><p></p><p></p><p> <strong>(A) AndroGel® 1%, testosterone gel applied to the skin of shoulders, upper arms, or abdomen mornings as either a 5 (unknown N) or 10 mg (unknown N) T daily dose. AbbVie Inc. / </strong></p><p><strong>[ATTACH=full]26658[/ATTACH]</strong></p><p><strong>Adapted from <a href="https://www.accessda.fda.gov/drugsatfda_docs/label/2013/021015s036lbl.pdf" target="_blank">https://www.accessda.fda.gov/drugsatfda_docs/label/2013/021015s036lbl.pdf</a>. / last accessed May 2022. </strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>(B) AndroGel® 1.62%, testosterone gel applied to the skin of upper arms and shoulders or rotational method of upper arms and shoulders plus abdomen mornings as an 81 mg T daily dose (N =33). AbbVie Inc. / </strong></p><p><strong>[ATTACH=full]26659[/ATTACH]</strong></p><p><strong>Adapted from </strong></p><p><strong><a href="https://www.rxabbvie.com/pdf/androgel1_" target="_blank">https://www.rxabbvie.com/pdf/androgel1_</a> 62_pi.pdf. / last accessed May 2022.</strong></p><p></p><p></p><p></p><p></p><p> <strong>(C) Axiron®, testosterone solution applied to the skin of axilla mornings (N =135) as either a 30, 60, 90, or 120 mg T daily dose. Lilly USA, LLC / </strong></p><p><strong>[ATTACH=full]26660[/ATTACH]</strong></p><p><strong>Adapted from </strong></p><p><strong><a href="https://www.accessdata.fda.gov/drugsatfda_" target="_blank">https://www.accessdata.fda.gov/drugsatfda_</a> docs/label/2017/022504s013lbl.pdf. / last accessed May 2022. </strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>(D) Fortesta®, testosterone gel applied in the mornings to the skin of thighs as a 40 mg T daily dose (N =12). Endo. </strong></p><p>[ATTACH=full]26661[/ATTACH]</p><p><strong>Adapted from <a href="https://www.accessdata.fda.gov/drugsatfda_docs/" target="_blank">https://www.accessdata.fda.gov/drugsatfda_docs/</a> label/2019/021463s020lbl.pdf. / last accessed May 2022. </strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>(E) Testim®, testosterone applied to shoulders and upper arms mornings (unknown N) as either a 50 mg or 100 mg T daily dose. Auxilium Pharmaceuticals, Inc. / </strong></p><p>[ATTACH=full]26662[/ATTACH]</p><p><strong>Adapted from <a href="https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021454s008lbl.pdf" target="_blank">https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021454s008lbl.pdf</a>. / last accessed May 2022. [Serum T concentration of the non-depicted biosimilar Vogelxo® is therapeutically equivalent to Testim® (<a href="https://www.accessdata" target="_blank">https://www.accessdata</a> .fda. gov/drugsatfda_docs/label/2019/204399s010lbl.pdf)]. </strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>(F) Natesto®, 5.5 mg of testosterone gel applied to each nostril at 6-8 h intervals during waking for a total daily T dose of 33 mg (N =69). Trimel BioPharma SRL / </strong></p><p>[ATTACH=full]26663[/ATTACH]</p><p><strong>Adapted from <a href="https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/205488s000lbl.pdf" target="_blank">https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/205488s000lbl.pdf</a>. / last accessed May 2022).</strong></p></blockquote><p></p>
[QUOTE="madman, post: 238234, member: 13851"] [B]Figure 2 Serum TT concentration 24 h pattern (with dispersion indices) under steady-state pharmacological conditions of each of the six nonbiosimilar FDA-approved gel and solution PA-TRTs. The horizontal axis of each graph shows the time in hours after the previous dose.[/B] [B](A) AndroGel® 1%, testosterone gel applied to the skin of shoulders, upper arms, or abdomen mornings as either a 5 (unknown N) or 10 mg (unknown N) T daily dose. AbbVie Inc. / [ATTACH type="full" alt="Screenshot (18393).png"]26658[/ATTACH] Adapted from [URL]https://www.accessda.fda.gov/drugsatfda_docs/label/2013/021015s036lbl.pdf[/URL]. / last accessed May 2022. (B) AndroGel® 1.62%, testosterone gel applied to the skin of upper arms and shoulders or rotational method of upper arms and shoulders plus abdomen mornings as an 81 mg T daily dose (N =33). AbbVie Inc. / [ATTACH type="full" alt="Screenshot (18394).png"]26659[/ATTACH] Adapted from [URL]https://www.rxabbvie.com/pdf/androgel1_[/URL] 62_pi.pdf. / last accessed May 2022.[/B] [B](C) Axiron®, testosterone solution applied to the skin of axilla mornings (N =135) as either a 30, 60, 90, or 120 mg T daily dose. Lilly USA, LLC / [ATTACH type="full" alt="Screenshot (18395).png"]26660[/ATTACH] Adapted from [URL]https://www.accessdata.fda.gov/drugsatfda_[/URL] docs/label/2017/022504s013lbl.pdf. / last accessed May 2022. (D) Fortesta®, testosterone gel applied in the mornings to the skin of thighs as a 40 mg T daily dose (N =12). Endo. [/B] [ATTACH type="full" alt="Screenshot (18396).png"]26661[/ATTACH] [B]Adapted from [URL]https://www.accessdata.fda.gov/drugsatfda_docs/[/URL] label/2019/021463s020lbl.pdf. / last accessed May 2022. (E) Testim®, testosterone applied to shoulders and upper arms mornings (unknown N) as either a 50 mg or 100 mg T daily dose. Auxilium Pharmaceuticals, Inc. / [/B] [ATTACH type="full" alt="Screenshot (18397).png"]26662[/ATTACH] [B]Adapted from [URL]https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021454s008lbl.pdf[/URL]. / last accessed May 2022. [Serum T concentration of the non-depicted biosimilar Vogelxo® is therapeutically equivalent to Testim® ([URL]https://www.accessdata[/URL] .fda. gov/drugsatfda_docs/label/2019/204399s010lbl.pdf)]. (F) Natesto®, 5.5 mg of testosterone gel applied to each nostril at 6-8 h intervals during waking for a total daily T dose of 33 mg (N =69). Trimel BioPharma SRL / [/B] [ATTACH type="full" alt="Screenshot (18398).png"]26663[/ATTACH] [B]Adapted from [URL]https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/205488s000lbl.pdf[/URL]. / last accessed May 2022).[/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Does Patient-Applied TRT Pose Risk for Blood Pressure Elevation?
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