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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Does nandrolone activate progesterone receptors?
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<blockquote data-quote="Cataceous" data-source="post: 212194" data-attributes="member: 38109"><p>The idea is that nandrolone is competing with endogenous progesterone to bind at the progesterone receptors. It only has 20% or so of the binding affinity of progesterone, but in sufficient amounts it would be displacing some progesterone from the receptors. If nandrolone activates the progesterone receptor as much as progesterone then the displacement of progesterone doesn't matter in terms of overall activity. But if nandrolone is weaker than progesterone in receptor activation, as claimed by [USER=40482]@benaoao[/USER], then it's possible for overall progestogenic activity to be reduced. However, sources such as Wikipedia refer to nandrolone as "a potent progestogen", and also list it as a PR agonist without qualification.</p><p></p><p>Furthermore, there are anecdotal reports that some guys who take only nandrolone supplement with estradiol. You'd think that would not be a viable strategy if nandrolone were already increasing estrogenic activity.</p><p></p><p></p><p>Yes, I think this is likely. Of course this assumes there's not additional suppression of endogenous progesterone caused by the nandrolone. Otherwise, assuming nandrolone is a full agonist of PR, then you could multiply the weight of the nandrolone you're taking by some factor, maybe 20%, and view that as the equivalent amount of progesterone you're getting.</p><p></p><p></p><p>I have seen <a href="https://raypeatforum.com/community/threads/vitamin-e-tocopherol-is-a-potent-aromatase-inhibitor.3106/" target="_blank">that post</a>, which says that vitamin E can antagonize estrogen receptors, inhibit aromatase, and also down-regulate aromatase expression. Of course it also says that "Vitamin E reduced androgen signaling without affecting androgen metabolism." This could be counterproductive.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 212194, member: 38109"] The idea is that nandrolone is competing with endogenous progesterone to bind at the progesterone receptors. It only has 20% or so of the binding affinity of progesterone, but in sufficient amounts it would be displacing some progesterone from the receptors. If nandrolone activates the progesterone receptor as much as progesterone then the displacement of progesterone doesn't matter in terms of overall activity. But if nandrolone is weaker than progesterone in receptor activation, as claimed by [USER=40482]@benaoao[/USER], then it's possible for overall progestogenic activity to be reduced. However, sources such as Wikipedia refer to nandrolone as "a potent progestogen", and also list it as a PR agonist without qualification. Furthermore, there are anecdotal reports that some guys who take only nandrolone supplement with estradiol. You'd think that would not be a viable strategy if nandrolone were already increasing estrogenic activity. Yes, I think this is likely. Of course this assumes there's not additional suppression of endogenous progesterone caused by the nandrolone. Otherwise, assuming nandrolone is a full agonist of PR, then you could multiply the weight of the nandrolone you're taking by some factor, maybe 20%, and view that as the equivalent amount of progesterone you're getting. I have seen [URL='https://raypeatforum.com/community/threads/vitamin-e-tocopherol-is-a-potent-aromatase-inhibitor.3106/']that post[/URL], which says that vitamin E can antagonize estrogen receptors, inhibit aromatase, and also down-regulate aromatase expression. Of course it also says that "Vitamin E reduced androgen signaling without affecting androgen metabolism." This could be counterproductive. [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Does nandrolone activate progesterone receptors?
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