But there's not long-term safety data, so people doing this are simply experimenting. They are also extrapolating from the benefits of normal levels over low levels. It's like saying that if 100 mg of testosterone per week makes hypogonadal men feel better then 1,000 mg per week must be 10 times better. The evidence for cancer prevention is deemed inconclusive, though there are positive associations in unblinded studies.[R]
Additionally, anyone thinking about mega-dosing should read up on the link between melatonin and prolactin.
