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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Does low estradiol cause joint pain in men because of inflammation?
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<blockquote data-quote="Nelson Vergel" data-source="post: 48397" data-attributes="member: 3"><p>Great question!</p><p></p><p>Yes, low estradiol can cause joint/muscle aches due to increased inflammation (high CRP is a parameter)</p><p></p><p>Low testosterone also can increase CRP. </p><p><strong><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866020/" target="_blank">Association of sex hormones and C-reactive protein levels in men</a></strong></p><p></p><p></p><p>"However, besides the well established positive effects of sex hormones in selected pathologies with a relevant inflammatory component, such as MS and osteoporosis, there is now a wealth of experimental models where the lack of endogenous estrogens facilitates the onset of inflammation that is antagonized by estrogen replacement. Examples of such models are: carrageenan-induced pleurisy, endotoxin-induced uveitis, experimental encephalomyelitis and adjuvant-induced arthritis and cutaneous wound healing.</p><p></p><p>In all of these models estradiol clearly opposes the inflammatory process." From: <a href="http://www.nature.com/mp/journal/v7/n3/full/4001007a.html" target="_blank"><strong>Estrogen and inflammation: hormone generous action spreads to the brain</strong></a></p><p></p><p>I am tired of warning men to be careful with high anastrozole doses (over 1 mg per week), and use of anabolic steroids that are DHT derivatives that reduce estradiol to undetectable blood levels. We also have data on how low estradiol makes you fat and lowers your libido.</p><p></p><p>The question really is what is high estradiol? Does that number depend on how high or low your testosterone is? We can spend hours on that is Dr Saya and I get into it.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 48397, member: 3"] Great question! Yes, low estradiol can cause joint/muscle aches due to increased inflammation (high CRP is a parameter) Low testosterone also can increase CRP. [B][URL='http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866020/']Association of sex hormones and C-reactive protein levels in men[/URL][/B] "However, besides the well established positive effects of sex hormones in selected pathologies with a relevant inflammatory component, such as MS and osteoporosis, there is now a wealth of experimental models where the lack of endogenous estrogens facilitates the onset of inflammation that is antagonized by estrogen replacement. Examples of such models are: carrageenan-induced pleurisy, endotoxin-induced uveitis, experimental encephalomyelitis and adjuvant-induced arthritis and cutaneous wound healing. In all of these models estradiol clearly opposes the inflammatory process." From: [URL='http://www.nature.com/mp/journal/v7/n3/full/4001007a.html'][B]Estrogen and inflammation: hormone generous action spreads to the brain[/B][/URL] I am tired of warning men to be careful with high anastrozole doses (over 1 mg per week), and use of anabolic steroids that are DHT derivatives that reduce estradiol to undetectable blood levels. We also have data on how low estradiol makes you fat and lowers your libido. The question really is what is high estradiol? Does that number depend on how high or low your testosterone is? We can spend hours on that is Dr Saya and I get into it. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Does low estradiol cause joint pain in men because of inflammation?
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