I can only speak to my experience. When my E2 was high, my acne was horrible. Now that I have better control of my E2 my acne problem has disappeared.
I remember when I tried pellets and my doctor overshot on the number of pellets and my T levels soared to 1600. My E2 also soared to over 100. My doctor would not put me on an aromatase inhibitor. My acne was worse than anytime since I was in high school for the next couple of months.
I switched to a T-cream about six weeks ago. I've only taken my anastrozole maybe twice in that time and can tell just by how I feel that my E2 is in range. Just wondering if the cream is going to help keep my hematocrits in range as well. I'm not due for labs for a while so this is based on how I feel.
J-