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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Does HCG raise estradiol more/faster than straight testosterone cypionate?
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<blockquote data-quote="Cataceous" data-source="post: 170249" data-attributes="member: 38109"><p>The serum half-life of testosterone released from a testosterone ester has little bearing on this question. The time to peak serum concentration is largely governed by the half-life of pure testosterone in serum, which is somewhere in the neighborhood of 10-100 minutes, best guess around 30 minutes. This leads to peak testosterone in the neighborhood of 2-6 hours post-injection. Serum estradiol has a half-life that's maybe an hour, which delays its peak by maybe a couple hours from the testosterone peak.</p><p></p><p>So with testosterone we can at least make some estimates about when estradiol will rise. But do we know what the situation is with hCG over these shorter periods? Even assuming rapid post-injection absorption, how long does it take to permeate the testicles? And after that, how long does it take to start stimulating the aromatization in Leydig cells? Must hCG raise intratesticular testosterone levels before efficient aromatization occurs, leading to a substantial delay? Without these answers I don't think it's possible to say whether hCG raises estradiol faster than testosterone esters.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 170249, member: 38109"] The serum half-life of testosterone released from a testosterone ester has little bearing on this question. The time to peak serum concentration is largely governed by the half-life of pure testosterone in serum, which is somewhere in the neighborhood of 10-100 minutes, best guess around 30 minutes. This leads to peak testosterone in the neighborhood of 2-6 hours post-injection. Serum estradiol has a half-life that's maybe an hour, which delays its peak by maybe a couple hours from the testosterone peak. So with testosterone we can at least make some estimates about when estradiol will rise. But do we know what the situation is with hCG over these shorter periods? Even assuming rapid post-injection absorption, how long does it take to permeate the testicles? And after that, how long does it take to start stimulating the aromatization in Leydig cells? Must hCG raise intratesticular testosterone levels before efficient aromatization occurs, leading to a substantial delay? Without these answers I don't think it's possible to say whether hCG raises estradiol faster than testosterone esters. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Does HCG raise estradiol more/faster than straight testosterone cypionate?
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