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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Does Anyone Lose Sensitivity While Taking An ED Drug?
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<blockquote data-quote="aneuman" data-source="post: 264059" data-attributes="member: 43264"><p>To answer your questions definitely and authoritatively, yes, I think that maybe I lost sensitivity using PDE5-i.</p><p></p><p>Obviously, hard to say, but I started cialis 5 mg daily for BPH many years ago. after a while, I started lasting longer, then too long. I can't say for sure, because the longer I took it, the older I got, so we have what may be considered confounding variables. I was not on TRT or any other thing, just Cialis. It happened after a few years of using it. Sensitivity improved shortly during my first HCG run, it's never been the same.</p><p></p><p>My hypothesis, it all has to do with estradiol. I don't want to start world war, but I think that in most people estradiol has to be between a narrow margin (inverted U curve) and values that are too low or too high cause symptoms. Perhaps the curve is flatter for some people and more pronounced in others, and that's while some people "let it ride" but a still there are diminished returns at some point. PDE5-i and <a href="https://pubmed.ncbi.nlm.nih.gov/16839328/" target="_blank">cialis in particular is known to change the T/E2 ratio</a> mainly by reducing Estradiol. The second part of my hypothesis is that while using HCG the first time, somehow while in flux, the values of E2, T, FT, DHT, etc hit the perfect spot at the same time (about 3 weeks) similarly to when the stars align and everything is fine. Or maybe it was that the starts aligned and that's why everything was fine.</p><p></p><p><a href="https://www.nature.com/articles/s41598-020-69712-6" target="_blank">Low estradiol is associated with delayed ejaculation</a> (less sensitivity?)</p><p></p><p>Exogenous HCG is known to increase estradiol in males. After using it for a while, it may have compensated for the decrease caused by cialis, but after continuous use the <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705979/" target="_blank">increase in estradiol may lead to erectyle disfunction</a></p><p></p><p>It seems you can't win.</p><p></p><p>I have not found the cure... just yet.</p><p></p><p>Good luck.</p></blockquote><p></p>
[QUOTE="aneuman, post: 264059, member: 43264"] To answer your questions definitely and authoritatively, yes, I think that maybe I lost sensitivity using PDE5-i. Obviously, hard to say, but I started cialis 5 mg daily for BPH many years ago. after a while, I started lasting longer, then too long. I can't say for sure, because the longer I took it, the older I got, so we have what may be considered confounding variables. I was not on TRT or any other thing, just Cialis. It happened after a few years of using it. Sensitivity improved shortly during my first HCG run, it's never been the same. My hypothesis, it all has to do with estradiol. I don't want to start world war, but I think that in most people estradiol has to be between a narrow margin (inverted U curve) and values that are too low or too high cause symptoms. Perhaps the curve is flatter for some people and more pronounced in others, and that's while some people "let it ride" but a still there are diminished returns at some point. PDE5-i and [URL='https://pubmed.ncbi.nlm.nih.gov/16839328/']cialis in particular is known to change the T/E2 ratio[/URL] mainly by reducing Estradiol. The second part of my hypothesis is that while using HCG the first time, somehow while in flux, the values of E2, T, FT, DHT, etc hit the perfect spot at the same time (about 3 weeks) similarly to when the stars align and everything is fine. Or maybe it was that the starts aligned and that's why everything was fine. [URL='https://www.nature.com/articles/s41598-020-69712-6']Low estradiol is associated with delayed ejaculation[/URL] (less sensitivity?) Exogenous HCG is known to increase estradiol in males. After using it for a while, it may have compensated for the decrease caused by cialis, but after continuous use the [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705979/']increase in estradiol may lead to erectyle disfunction[/URL] It seems you can't win. I have not found the cure... just yet. Good luck. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Does Anyone Lose Sensitivity While Taking An ED Drug?
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