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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Doctor will not perform surgery
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<blockquote data-quote="DragonBits" data-source="post: 156817" data-attributes="member: 18023"><p>It wasn't that far off.</p><p></p><p>My shbg shot up form 40 > 70, my free T stayed at about 1.4-1.7% of total T regardless of my shbg.</p><p></p><p>However, my E2 changed from 3-4.14% of total T when my shbg was around 40 to 1.98-2.5% when my shbg was 70.</p><p></p><p>I don't know it was the rise in shbg that dropped E2 percentage of total T, the supplements i took that likely caused shbg to rise may have caused E2 percentage to drop by a different and independent means. </p><p></p><p>Another thing I am unsure about, estradiol is created from testosterone, but is it from total T or whatever free T is left after binding to shbg? </p><p></p><p>When testosterone is cleaved from the ester it is attached to, I can't believe that testosterone is immediately bound to shbg, there must be a lag time between when testosterone is in the blood stream and when it gets bound to shbg. So I am guessing there must for however short a time be a big rise in free T, if only locally near the injection site.</p><p></p><p>IMO when you try and get down to the nitty gritty details, it's all a little complicated.</p><p></p><p>I tend to only pay attention to total T, some attention to E2 and only if it's over 50 or under 20, getting a free T measure is interesting but what should I do about it?</p><p></p><p>I did virtual no blood tests for 5 years on TRT when I self directed, the last few years I did a lot of blood tests, way more than needed, now I am returning to the feeling I don't really need to get blood tests once I am dialed in, but I do only do it now because doctors want it.</p><p></p><p>The theory is interesting, but it's not like I am a clinician needing to treat a lot of different men that may react in different ways, I only need to concern myself about how i react, and I have a pretty good idea now.</p></blockquote><p></p>
[QUOTE="DragonBits, post: 156817, member: 18023"] It wasn't that far off. My shbg shot up form 40 > 70, my free T stayed at about 1.4-1.7% of total T regardless of my shbg. However, my E2 changed from 3-4.14% of total T when my shbg was around 40 to 1.98-2.5% when my shbg was 70. I don't know it was the rise in shbg that dropped E2 percentage of total T, the supplements i took that likely caused shbg to rise may have caused E2 percentage to drop by a different and independent means. Another thing I am unsure about, estradiol is created from testosterone, but is it from total T or whatever free T is left after binding to shbg? When testosterone is cleaved from the ester it is attached to, I can't believe that testosterone is immediately bound to shbg, there must be a lag time between when testosterone is in the blood stream and when it gets bound to shbg. So I am guessing there must for however short a time be a big rise in free T, if only locally near the injection site. IMO when you try and get down to the nitty gritty details, it's all a little complicated. I tend to only pay attention to total T, some attention to E2 and only if it's over 50 or under 20, getting a free T measure is interesting but what should I do about it? I did virtual no blood tests for 5 years on TRT when I self directed, the last few years I did a lot of blood tests, way more than needed, now I am returning to the feeling I don't really need to get blood tests once I am dialed in, but I do only do it now because doctors want it. The theory is interesting, but it's not like I am a clinician needing to treat a lot of different men that may react in different ways, I only need to concern myself about how i react, and I have a pretty good idea now. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Doctor will not perform surgery
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