ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
General Health & Fitness
Health & Wellness
Do statins affect erections in men?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Nelson Vergel" data-source="post: 17446" data-attributes="member: 3"><p>Cederberg H, Stancakova A, Yaluri N, Modi S, Kuusisto J, et al.<strong></strong></p><p><strong></strong></p><p> <strong>Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6</strong> <strong>year follow-up study of the METSIM cohort. </strong></p><p><strong></strong></p><p><strong>Diabetologia. 2015;58(5):1109-17. <a href="http://link.springer.com/article/10.1007%2Fs00125-015-3528-5" target="_blank">http://link.springer.com/article/10.1007/s00125-015-3528-5</a> </strong></p><p></p><p></p><p>Aims/Hypothesis - The aim of this work was to investigate the mechanisms underlying the risk of type 2 diabetes associated with statin treatment in the population-based Metabolic Syndrome in Men (METSIM) cohort.</p><p></p><p></p><p>Methods - A total of 8,749 non-diabetic participants, aged 45&#8211;73 years, were followed up for 5.9 years. New diabetes was diagnosed in 625 men by means of an OGTT, HbA1c &#8805;6.5% (48 mmol/mol) or glucose-lowering medication started during the follow-up. Insulin sensitivity and secretion were evaluated with OGTT-derived indices.</p><p></p><p></p><p>Results - Participants on statin treatment (N&#8201;=&#8201;2,142) had a 46% increased risk of type 2 diabetes (adjusted HR 1.46 [95% CI 1.22, 1.74]). The risk was dose dependent for simvastatin and atorvastatin. Statin treatment significantly increased 2 h glucose (2hPG) and glucose AUC of an OGTT at follow-up, with a nominally significant increase in fasting plasma glucose (FPG). </p><p></p><p></p><p>Insulin sensitivity was decreased by 24% and insulin secretion by 12% in individuals on statin treatment (at FPG and 2hPG <5.0 mmol/l) compared with individuals without statin treatment (p&#8201;<&#8201;0.01). Decreases in insulin sensitivity and insulin secretion were dose dependent for simvastatin and atorvastatin.</p><p></p><p></p><p>Conclusions/Interpretation - Statin treatment increased the risk of type 2 diabetes by 46%, attributable to decreases in insulin sensitivity and insulin secretion.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 17446, member: 3"] Cederberg H, Stancakova A, Yaluri N, Modi S, Kuusisto J, et al.[B] Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6[/B] [B]year follow-up study of the METSIM cohort. Diabetologia. 2015;58(5):1109-17. [URL]http://link.springer.com/article/10.1007%2Fs00125-015-3528-5[/URL] [/B] Aims/Hypothesis - The aim of this work was to investigate the mechanisms underlying the risk of type 2 diabetes associated with statin treatment in the population-based Metabolic Syndrome in Men (METSIM) cohort. Methods - A total of 8,749 non-diabetic participants, aged 45–73 years, were followed up for 5.9 years. New diabetes was diagnosed in 625 men by means of an OGTT, HbA1c ≥6.5% (48 mmol/mol) or glucose-lowering medication started during the follow-up. Insulin sensitivity and secretion were evaluated with OGTT-derived indices. Results - Participants on statin treatment (N = 2,142) had a 46% increased risk of type 2 diabetes (adjusted HR 1.46 [95% CI 1.22, 1.74]). The risk was dose dependent for simvastatin and atorvastatin. Statin treatment significantly increased 2 h glucose (2hPG) and glucose AUC of an OGTT at follow-up, with a nominally significant increase in fasting plasma glucose (FPG). Insulin sensitivity was decreased by 24% and insulin secretion by 12% in individuals on statin treatment (at FPG and 2hPG <5.0 mmol/l) compared with individuals without statin treatment (p < 0.01). Decreases in insulin sensitivity and insulin secretion were dose dependent for simvastatin and atorvastatin. Conclusions/Interpretation - Statin treatment increased the risk of type 2 diabetes by 46%, attributable to decreases in insulin sensitivity and insulin secretion. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
General Health & Fitness
Health & Wellness
Do statins affect erections in men?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top