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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Do i need more testosterone? Testosterone non responder?
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<blockquote data-quote="madman" data-source="post: 148918" data-attributes="member: 13851"><p>No one is saying you have to stay in the reference range for TT/FT as there is nothing wrong with one running a higher TT 1200+ or FT level in the 30-50 ng/dL as long as one is not experiencing any side effects and blood markers are in a healthy range.....but again depending on ones SHBG whether high/normal/low it comes down to what <strong>TT does one need to achieve a healthy FT in order to experience relief/improvement of low-t symptoms while minimizing side effects and keeping blood markers in a healthy range.</strong></p><p></p><p>Most men would do well with a FT in the 20-30 ng/dL range where as others may need levels higher.</p><p></p><p>Not everyone can handle running higher TT/FT levels and in cases of low SHBG running too high a FT level would result in high e2/free estradiol which can end up putting a damper on running an effective protocol unless an aromatase inhibitor is used sensibly.....although it would be preferable if one could get away without having to use an a.i.</p><p></p><p>Do understand that one with a higher SHBG would need to run a higher TT in order to achieve the same FT levels compared to one with low SHBG.</p><p></p><p>As I stated previously:</p><p></p><p>If we use the <strong><span style="color: rgb(184, 49, 47)">TruT </span>Free Testosterone Calculator by</strong> <span style="color: rgb(184, 49, 47)"><strong>FPT</strong></span></p><p></p><p>Taking your <strong>TT 779 ng/dL</strong>, <strong><span style="color: rgb(184, 49, 47)">SHBG 14.4 nmol/L</span> </strong>and<strong> <span style="color: rgb(44, 130, 201)">Albumin 4.3 g/dL</span></strong> <strong>(<span style="color: rgb(44, 130, 201)">mean</span>)</strong></p><p>than your <strong><span style="color: rgb(184, 49, 47)">FT 29.31 ng/dL</span></strong> would be in top of the<strong> reference range <span style="color: rgb(184, 49, 47)">16-31 ng/dL</span></strong></p><p></p><p>Now your FT levels are near the top of the reference range at trough.....again most likely your e2/free estradiol is high but again we have no idea where your e2/free estradiol truly sits due to not having access to the proper testing method.</p><p></p><p>Can you try running higher FT levels.....sure but do understand that not only will your e2/free estradiol increase but it will result in an increased hemoglobin/hematocrit level and possibly have a negative effect on lipids (decrease HDL).</p><p></p><p>I would tread lightly trying to push your TT/FT levels really high seeing as you have low SHBG.</p><p></p><p>As an example if you wanted to push your<span style="color: rgb(44, 130, 201)"> <strong>FT </strong></span>levels close to the upper end <strong><span style="color: rgb(44, 130, 201)">50 ng/dl</span></strong> (well over the <strong>reference range of <span style="color: rgb(184, 49, 47)">16-31 ng/dL</span></strong> -<strong><span style="color: rgb(184, 49, 47)">TruT</span> Free Testosterone Calculator by</strong> <span style="color: rgb(184, 49, 47)"><strong>FPT</strong></span></p><p></p><p>Than with your <span style="color: rgb(184, 49, 47)"><strong>SHBG of 14.4 nmol/L</strong></span> you would need to run a <strong>TT of 1300 ng/dL</strong> to achieve a <span style="color: rgb(44, 130, 201)"><strong>FT of 49.86 ng/dL</strong></span></p><p>[ATTACH=full]7475[/ATTACH]</p><p></p><p></p><p></p><p>Looking at one with<strong><span style="color: rgb(184, 49, 47)"> high SHBG 70 nmol/L </span></strong>they would need to run a <strong>TT of roughly 1500 ng/dL </strong>to achieve a <strong><span style="color: rgb(44, 130, 201)">FT of 50.28 ng/dL</span></strong></p><p>[ATTACH=full]7476[/ATTACH]</p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong>The one that says go as high as possible with testosterone to relieve symptoms. Even if this means total t of 1200-1600 or above and free t 30-50 ng/dl with just letting the estrogen go even if its 100 pg/ml. <span style="color: rgb(184, 49, 47)">And never use an AI. (dr nichols, neil rouzier etc)</span></strong></p><p></p><p>Both solely prefer the transdermal method and one is notorious for transdermal cream scrotal application (twice daily am/pm) and one of the main benefits is a large increase in DHT which may negate the effects of high e2.</p><p></p><p>Doubtful many using injectable could tolerate running TT 1500+.....let alone 1200+ without experiencing negative effects due to very high FT levels.</p><p></p><p>Even than using transdermal whether standard body application or scrotally some would not be able to handle running such high TT/FT levels.</p><p></p><p>If anything one would have to run TT levels of 1300-1500+ to achieve FT levels in the 50 ng/dL range and only in cases of absurdly high SHBG levels 100 nmol/L (or higher) or possible AR resistance (older men or previous steroid users) would one need to run TT levels of 1600+ ng/dL.</p><p></p><p>Regarding these doctors stating running FT levels in the 30-50 ng/dL range are you sure their patients FT levels are all tested using the<strong><span style="color: rgb(251, 160, 38)"> gold standard </span></strong><span style="color: rgb(44, 130, 201)"><strong>equilibrium dialysis</strong></span> or taking their <strong>TT,<span style="color: rgb(184, 49, 47)">SHBG</span>,<span style="color: rgb(44, 130, 201)">Albumin</span></strong> and using the:</p><p></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">TruT™</span> by <span style="color: rgb(184, 49, 47)">FPT</span></strong></p><p><strong>The <em>novel</em>, FDA-registered <span style="color: rgb(184, 49, 47)">TruT™ </span>algorithm uses modern understanding of molecular interactions to improve the accuracy of free-T calculations.</strong></p><p></p><p></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">*</span> For all we know these patients <span style="color: rgb(184, 49, 47)">FT levels </span>whether <span style="color: rgb(184, 49, 47)">30-60 ng/dL</span> are done using flawed FT testing methods!</strong></p></blockquote><p></p>
[QUOTE="madman, post: 148918, member: 13851"] No one is saying you have to stay in the reference range for TT/FT as there is nothing wrong with one running a higher TT 1200+ or FT level in the 30-50 ng/dL as long as one is not experiencing any side effects and blood markers are in a healthy range.....but again depending on ones SHBG whether high/normal/low it comes down to what [B]TT does one need to achieve a healthy FT in order to experience relief/improvement of low-t symptoms while minimizing side effects and keeping blood markers in a healthy range.[/B] Most men would do well with a FT in the 20-30 ng/dL range where as others may need levels higher. Not everyone can handle running higher TT/FT levels and in cases of low SHBG running too high a FT level would result in high e2/free estradiol which can end up putting a damper on running an effective protocol unless an aromatase inhibitor is used sensibly.....although it would be preferable if one could get away without having to use an a.i. Do understand that one with a higher SHBG would need to run a higher TT in order to achieve the same FT levels compared to one with low SHBG. As I stated previously: If we use the [B][COLOR=rgb(184, 49, 47)]TruT [/COLOR]Free Testosterone Calculator by[/B] [COLOR=rgb(184, 49, 47)][B]FPT[/B][/COLOR] Taking your [B]TT 779 ng/dL[/B], [B][COLOR=rgb(184, 49, 47)]SHBG 14.4 nmol/L[/COLOR] [/B]and[B] [COLOR=rgb(44, 130, 201)]Albumin 4.3 g/dL[/COLOR][/B] [B]([COLOR=rgb(44, 130, 201)]mean[/COLOR])[/B] than your [B][COLOR=rgb(184, 49, 47)]FT 29.31 ng/dL[/COLOR][/B] would be in top of the[B] reference range [COLOR=rgb(184, 49, 47)]16-31 ng/dL[/COLOR][/B] Now your FT levels are near the top of the reference range at trough.....again most likely your e2/free estradiol is high but again we have no idea where your e2/free estradiol truly sits due to not having access to the proper testing method. Can you try running higher FT levels.....sure but do understand that not only will your e2/free estradiol increase but it will result in an increased hemoglobin/hematocrit level and possibly have a negative effect on lipids (decrease HDL). I would tread lightly trying to push your TT/FT levels really high seeing as you have low SHBG. As an example if you wanted to push your[COLOR=rgb(44, 130, 201)] [B]FT [/B][/COLOR]levels close to the upper end [B][COLOR=rgb(44, 130, 201)]50 ng/dl[/COLOR][/B] (well over the [B]reference range of [COLOR=rgb(184, 49, 47)]16-31 ng/dL[/COLOR][/B] -[B][COLOR=rgb(184, 49, 47)]TruT[/COLOR] Free Testosterone Calculator by[/B] [COLOR=rgb(184, 49, 47)][B]FPT[/B][/COLOR] Than with your [COLOR=rgb(184, 49, 47)][B]SHBG of 14.4 nmol/L[/B][/COLOR] you would need to run a [B]TT of 1300 ng/dL[/B] to achieve a [COLOR=rgb(44, 130, 201)][B]FT of 49.86 ng/dL[/B][/COLOR] [ATTACH=full]7475[/ATTACH] Looking at one with[B][COLOR=rgb(184, 49, 47)] high SHBG 70 nmol/L [/COLOR][/B]they would need to run a [B]TT of roughly 1500 ng/dL [/B]to achieve a [B][COLOR=rgb(44, 130, 201)]FT of 50.28 ng/dL[/COLOR][/B] [ATTACH=full]7476[/ATTACH] [B]The one that says go as high as possible with testosterone to relieve symptoms. Even if this means total t of 1200-1600 or above and free t 30-50 ng/dl with just letting the estrogen go even if its 100 pg/ml. [COLOR=rgb(184, 49, 47)]And never use an AI. (dr nichols, neil rouzier etc)[/COLOR][/B] Both solely prefer the transdermal method and one is notorious for transdermal cream scrotal application (twice daily am/pm) and one of the main benefits is a large increase in DHT which may negate the effects of high e2. Doubtful many using injectable could tolerate running TT 1500+.....let alone 1200+ without experiencing negative effects due to very high FT levels. Even than using transdermal whether standard body application or scrotally some would not be able to handle running such high TT/FT levels. If anything one would have to run TT levels of 1300-1500+ to achieve FT levels in the 50 ng/dL range and only in cases of absurdly high SHBG levels 100 nmol/L (or higher) or possible AR resistance (older men or previous steroid users) would one need to run TT levels of 1600+ ng/dL. Regarding these doctors stating running FT levels in the 30-50 ng/dL range are you sure their patients FT levels are all tested using the[B][COLOR=rgb(251, 160, 38)] gold standard [/COLOR][/B][COLOR=rgb(44, 130, 201)][B]equilibrium dialysis[/B][/COLOR] or taking their [B]TT,[COLOR=rgb(184, 49, 47)]SHBG[/COLOR],[COLOR=rgb(44, 130, 201)]Albumin[/COLOR][/B] and using the: [B][COLOR=rgb(184, 49, 47)]TruT™[/COLOR] by [COLOR=rgb(184, 49, 47)]FPT[/COLOR] The [I]novel[/I], FDA-registered [COLOR=rgb(184, 49, 47)]TruT™ [/COLOR]algorithm uses modern understanding of molecular interactions to improve the accuracy of free-T calculations.[/B] [B][COLOR=rgb(184, 49, 47)]*[/COLOR] For all we know these patients [COLOR=rgb(184, 49, 47)]FT levels [/COLOR]whether [COLOR=rgb(184, 49, 47)]30-60 ng/dL[/COLOR] are done using flawed FT testing methods![/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Do i need more testosterone? Testosterone non responder?
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