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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Do i need more testosterone? Testosterone non responder?
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<blockquote data-quote="madman" data-source="post: 148881" data-attributes="member: 13851"><p>When were your labs done (trough)?</p><p></p><p>I have stated this many times and I will say it again....<strong><span style="color: rgb(184, 49, 47)">.although relief/improvement of low-t symptoms is what truly matters </span></strong>as oppose to <strong>just where numbers fall in a reference range</strong>.....<strong><span style="color: rgb(184, 49, 47)">lab work is still critical</span></strong> not only for making sure <strong><span style="color: rgb(184, 49, 47)">blood markers are in a healthy range</span></strong> but to also see how <strong><span style="color: rgb(44, 130, 201)">said dose of testosterone effects ones TT/FT/DHT/e2 levels</span></strong> as an effective trt protocol will come down to <span style="color: rgb(44, 130, 201)"><strong>most importantly ones SHBG levels </strong></span>and what <strong><span style="color: rgb(184, 49, 47)">dose of T/injection frequency</span></strong> is needed <span style="color: rgb(184, 49, 47)"><strong>to</strong></span> <strong><span style="color: rgb(184, 49, 47)">achieve a TT </span></strong>that will result in <span style="color: rgb(184, 49, 47)"><strong>a healthy FT level.</strong></span></p><p></p><p>Unfortunately regarding testing ones <strong><span style="color: rgb(184, 49, 47)">FT (free testosterone) </span></strong>most are using the <strong><span style="color: rgb(26, 188, 156)">direct analog-based free testosterone immunoassays</span></strong> which are <strong><span style="color: rgb(26, 188, 156)">inaccurate.</span></strong></p><p></p><p>If anything you should be getting the <strong><span style="color: rgb(44, 130, 201)">equilibrium dialysis</span></strong> or better yet save yourself the money and use the<strong> Calculate free testosterone with <span style="color: rgb(184, 49, 47)">TruT </span>by <span style="color: rgb(184, 49, 47)">FPT</span> - </strong><a href="https://tru-t.org/" target="_blank">Try the public free testosterone calculator at tru-t.org</a></p><p></p><p>Do you truly know your FT levels?</p><p></p><p></p><p></p><p><strong>Testosterone, Free, Mass Spectrometry/Equilibrium Dialysis (Endocrine Sciences)</strong></p><p></p><p>TEST: 500726</p><p>Test number copied</p><p></p><p>CPT: 84402; 84403</p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong>Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline (2018)</strong></p><p></p><p></p><p><a href="https://academic.oup.com/jcem/article/103/5/1715/4939465" target="_blank">Testosterone Therapy in Men With Hypogonadism: An Endocrine Society * Clinical Practice Guideline</a></p><p></p><p></p><p></p><p><strong>In men who have conditions that alter<span style="color: rgb(184, 49, 47)"> sex hormone–binding globulin (SHBG) (</span><span style="color: rgb(0, 0, 0)">Table 2</span><span style="color: rgb(184, 49, 47)">)</span>,</strong> <strong>or whose <span style="color: rgb(184, 49, 47)">initial total testosterone concentrations</span> are <span style="color: rgb(184, 49, 47)">at or near the lower limit</span> of the <span style="color: rgb(184, 49, 47)">normal range</span></strong> <strong><span style="color: rgb(184, 49, 47)">(</span>Fig. 1<span style="color: rgb(184, 49, 47)">)</span>,</strong> <strong>clinicians should determine <span style="color: rgb(44, 130, 201)">free testosterone concentrations</span> either <span style="color: rgb(44, 130, 201)">directly from equilibrium dialysis assays</span> or by <span style="color: rgb(44, 130, 201)">calculations that use total testosterone, SHBG, and albumin concentrations. </span>Clinicians should <span style="color: rgb(26, 188, 156)">not use direct analog-based free testosterone immunoassays</span>, as they are<span style="color: rgb(26, 188, 156)"> inaccurate.</span></strong></p><p></p><p></p><p></p><p>Seeing as you tested your FT using the wrong assay (<strong><span style="color: rgb(184, 49, 47)">free t 25ng/dl</span></strong> range: 4-13ng/dl)</p><p></p><p></p><p>If we use the <strong><span style="color: rgb(184, 49, 47)">TruT </span>Free Testosterone Calculator by</strong> <span style="color: rgb(184, 49, 47)">FPT</span></p><p></p><p>Taking your <strong>TT 779 ng/dL</strong>, <strong><span style="color: rgb(184, 49, 47)">SHBG 14.4 nmol/L </span></strong>and<span style="color: rgb(44, 130, 201)"><strong> Albumin 4.3 g/dL</strong></span> <strong>(<span style="color: rgb(44, 130, 201)">mean</span>)</strong></p><p>than your <span style="color: rgb(184, 49, 47)"><strong>FT 29.31 ng/dL</strong></span> would be in top of the<strong> reference range <span style="color: rgb(184, 49, 47)">16-31 ng/dL</span></strong></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">[ATTACH=full]7473[/ATTACH]</span></strong></p><p></p><p>If anything it could very well be that seeing as you have low SHBG and your FT is on the high end I would be that your e2 but more importantly free estradiol is high and could definitely have a negative effect on how you feel on such protocol sustanon 250 (65mg EOD)!</p><p></p><p>Oh but your did not have your e2 tested?</p><p></p><p>You stated that you tried daily injections <strong><span style="color: rgb(184, 49, 47)">"I am a low shbg guy so i tried the daily shots but that makes me feel even worse"</span></strong>.....yet you post no lab work let alone we have no idea how much time you truly invested in trying such protocol as you go on and state <strong><span style="color: rgb(184, 49, 47)">"All this hassle with injecting eod and using 230 mg a week to get medium levels"</span></strong>....6 weeks minimum should be done to say the least!</p></blockquote><p></p>
[QUOTE="madman, post: 148881, member: 13851"] When were your labs done (trough)? I have stated this many times and I will say it again....[B][COLOR=rgb(184, 49, 47)].although relief/improvement of low-t symptoms is what truly matters [/COLOR][/B]as oppose to [B]just where numbers fall in a reference range[/B].....[B][COLOR=rgb(184, 49, 47)]lab work is still critical[/COLOR][/B] not only for making sure [B][COLOR=rgb(184, 49, 47)]blood markers are in a healthy range[/COLOR][/B] but to also see how [B][COLOR=rgb(44, 130, 201)]said dose of testosterone effects ones TT/FT/DHT/e2 levels[/COLOR][/B] as an effective trt protocol will come down to [COLOR=rgb(44, 130, 201)][B]most importantly ones SHBG levels [/B][/COLOR]and what [B][COLOR=rgb(184, 49, 47)]dose of T/injection frequency[/COLOR][/B] is needed [COLOR=rgb(184, 49, 47)][B]to[/B][/COLOR] [B][COLOR=rgb(184, 49, 47)]achieve a TT [/COLOR][/B]that will result in [COLOR=rgb(184, 49, 47)][B]a healthy FT level.[/B][/COLOR] Unfortunately regarding testing ones [B][COLOR=rgb(184, 49, 47)]FT (free testosterone) [/COLOR][/B]most are using the [B][COLOR=rgb(26, 188, 156)]direct analog-based free testosterone immunoassays[/COLOR][/B] which are [B][COLOR=rgb(26, 188, 156)]inaccurate.[/COLOR][/B] If anything you should be getting the [B][COLOR=rgb(44, 130, 201)]equilibrium dialysis[/COLOR][/B] or better yet save yourself the money and use the[B] Calculate free testosterone with [COLOR=rgb(184, 49, 47)]TruT [/COLOR]by [COLOR=rgb(184, 49, 47)]FPT[/COLOR] - [/B][URL='https://tru-t.org/']Try the public free testosterone calculator at tru-t.org[/URL] Do you truly know your FT levels? [B]Testosterone, Free, Mass Spectrometry/Equilibrium Dialysis (Endocrine Sciences)[/B] TEST: 500726 Test number copied CPT: 84402; 84403 [B]Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline (2018)[/B] [URL='https://academic.oup.com/jcem/article/103/5/1715/4939465']Testosterone Therapy in Men With Hypogonadism: An Endocrine Society * Clinical Practice Guideline[/URL] [B]In men who have conditions that alter[COLOR=rgb(184, 49, 47)] sex hormone–binding globulin (SHBG) ([/COLOR][COLOR=rgb(0, 0, 0)]Table 2[/COLOR][COLOR=rgb(184, 49, 47)])[/COLOR],[/B] [B]or whose [COLOR=rgb(184, 49, 47)]initial total testosterone concentrations[/COLOR] are [COLOR=rgb(184, 49, 47)]at or near the lower limit[/COLOR] of the [COLOR=rgb(184, 49, 47)]normal range[/COLOR][/B] [B][COLOR=rgb(184, 49, 47)]([/COLOR]Fig. 1[COLOR=rgb(184, 49, 47)])[/COLOR],[/B] [B]clinicians should determine[COLOR=rgb(184, 49, 47)] [/COLOR][COLOR=rgb(44, 130, 201)]free testosterone concentrations[/COLOR][COLOR=rgb(184, 49, 47)] [/COLOR]either [COLOR=rgb(44, 130, 201)]directly from equilibrium dialysis assays[/COLOR] or by [COLOR=rgb(44, 130, 201)]calculations that use total testosterone, SHBG, and albumin concentrations. [/COLOR]Clinicians should [COLOR=rgb(26, 188, 156)]not use direct analog-based free testosterone immunoassays[/COLOR], as they are[COLOR=rgb(26, 188, 156)] inaccurate.[/COLOR][/B] Seeing as you tested your FT using the wrong assay ([B][COLOR=rgb(184, 49, 47)]free t 25ng/dl[/COLOR][/B] range: 4-13ng/dl) If we use the [B][COLOR=rgb(184, 49, 47)]TruT [/COLOR]Free Testosterone Calculator by[/B] [COLOR=rgb(184, 49, 47)]FPT[/COLOR] Taking your [B]TT 779 ng/dL[/B], [B][COLOR=rgb(184, 49, 47)]SHBG 14.4 nmol/L [/COLOR][/B]and[COLOR=rgb(44, 130, 201)][B] Albumin 4.3 g/dL[/B][/COLOR] [B]([COLOR=rgb(44, 130, 201)]mean[/COLOR])[/B] than your [COLOR=rgb(184, 49, 47)][B]FT 29.31 ng/dL[/B][/COLOR] would be in top of the[B] reference range [COLOR=rgb(184, 49, 47)]16-31 ng/dL[/COLOR][/B] [B][COLOR=rgb(184, 49, 47)][ATTACH=full]7473[/ATTACH][/COLOR][/B] If anything it could very well be that seeing as you have low SHBG and your FT is on the high end I would be that your e2 but more importantly free estradiol is high and could definitely have a negative effect on how you feel on such protocol sustanon 250 (65mg EOD)! Oh but your did not have your e2 tested? You stated that you tried daily injections [B][COLOR=rgb(184, 49, 47)]"I am a low shbg guy so i tried the daily shots but that makes me feel even worse"[/COLOR][/B].....yet you post no lab work let alone we have no idea how much time you truly invested in trying such protocol as you go on and state [B][COLOR=rgb(184, 49, 47)]"All this hassle with injecting eod and using 230 mg a week to get medium levels"[/COLOR][/B]....6 weeks minimum should be done to say the least! [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Do i need more testosterone? Testosterone non responder?
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