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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Do higher estrogen levels in men on TRT make them more emotional or irritable?
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<blockquote data-quote="trtthings" data-source="post: 192127" data-attributes="member: 41094"><p>I'm not sure how much E2 is necessary for me but at a certain point I can be on the brink of tears from nothing. </p><p></p><p><a href="https://pubmed.ncbi.nlm.nih.gov/29107881/" target="_blank">Increased estrogen level can be associated with depression in males - PubMed</a> - somewhat interesting.</p><p></p><p><strong>Results: </strong>Obese men had compared to normal weight controls <strong>lower total testosterone</strong> (<strong>12.6</strong>±4.7 vs <strong>19.4</strong>±5.5 nmol/L, p<0.001 in <60years, and <strong>13.8</strong>±6.9 vs <strong>18.3</strong>±5.9 nmol/L, p<0.001 in >60years group) and free testosterone (<strong>249</strong>.0±73.9 vs <strong>337</strong>.2±82.0pmol/L, p<0.001, and <strong>217</strong>.8±71.2 vs <strong>263</strong>.4±72.2pmol/L, p<0.001), and increased estradiol in older group only (97.3±43.0 vs 82.3±34.2pmol/L, p<0.001 in obese). Men <60years old <strong>with depressive symptomatology had higher estradiol levels compared to those without depressive symptomatology</strong> (<strong>96.3</strong>±40.7 vs <strong>84.4</strong>±36.6pmol/L, p<0.001), however no association with BMI was observed.</p><p></p><p>Very little difference in estradiol though, but agrees with my experience.</p></blockquote><p></p>
[QUOTE="trtthings, post: 192127, member: 41094"] I'm not sure how much E2 is necessary for me but at a certain point I can be on the brink of tears from nothing. [URL="https://pubmed.ncbi.nlm.nih.gov/29107881/"]Increased estrogen level can be associated with depression in males - PubMed[/URL] - somewhat interesting. [B]Results: [/B]Obese men had compared to normal weight controls [B]lower total testosterone[/B] ([B]12.6[/B]±4.7 vs [B]19.4[/B]±5.5 nmol/L, p<0.001 in <60years, and [B]13.8[/B]±6.9 vs [B]18.3[/B]±5.9 nmol/L, p<0.001 in >60years group) and free testosterone ([B]249[/B].0±73.9 vs [B]337[/B].2±82.0pmol/L, p<0.001, and [B]217[/B].8±71.2 vs [B]263[/B].4±72.2pmol/L, p<0.001), and increased estradiol in older group only (97.3±43.0 vs 82.3±34.2pmol/L, p<0.001 in obese). Men <60years old [B]with depressive symptomatology had higher estradiol levels compared to those without depressive symptomatology[/B] ([B]96.3[/B]±40.7 vs [B]84.4[/B]±36.6pmol/L, p<0.001), however no association with BMI was observed. Very little difference in estradiol though, but agrees with my experience. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Do higher estrogen levels in men on TRT make them more emotional or irritable?
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