ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Do changes in body weight affect dose response?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Cataceous" data-source="post: 270608" data-attributes="member: 38109"><p>As the others have said, there are many possible influences on your results, including vial mis-dosing and lab errors. My current thinking is that changes in body weight should not have much of a direct effect. The metabolism of testosterone occurs primarily in the liver. I doubt the rate changes much unless there are significant insults to the organ.</p><p></p><p>Indirectly, changes in body composition could in theory affect the rate of depot absorption. Slower absorption would lead to lower peaks and higher troughs, even as average levels remain unchanged.</p><p></p><p>I can't predict if the 12 mg/week reduction in TE will be enough, but it does seem likely that you'll see a reduction in HCT if other variables are held constant. A benefit of lowering the dose slowly is that you may avoid withdrawal-type symptoms that many complain about. Such symptoms are reported to resolve within a few months. Many who aren't aware of this assume it's a return to hypogonadism and give up prematurely. It's good to recall that there is a threshold effect for hypogonadism; for the vast majority of men, symptoms will not occur if total testosterone reaches somewhere in the 400s ng/dL each day, assuming normal SHBG.</p><p></p><p>I no longer use hCG, and even when I did, the production of endogenous testosterone seemed to be minimal. </p><p></p><p>One reason why I need less testosterone is that I use a blend of testosterone enanthate and testosterone propionate, injected daily. Natural men have a diurnal rhythm, with serum testosterone highest in the early morning. The TE/TP blend attempts to mimic this to an extent. The hypothesis is that some benefits of testosterone derive from daily peak levels, whereas side effects are more driven by trough or average levels. This concept is supported by the clinical trials for Natesto. Many of these men have quite low baseline testosterone, but the three large, but relatively brief testosterone pulses each day are sufficient to resolve hypogonadism.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 270608, member: 38109"] As the others have said, there are many possible influences on your results, including vial mis-dosing and lab errors. My current thinking is that changes in body weight should not have much of a direct effect. The metabolism of testosterone occurs primarily in the liver. I doubt the rate changes much unless there are significant insults to the organ. Indirectly, changes in body composition could in theory affect the rate of depot absorption. Slower absorption would lead to lower peaks and higher troughs, even as average levels remain unchanged. I can't predict if the 12 mg/week reduction in TE will be enough, but it does seem likely that you'll see a reduction in HCT if other variables are held constant. A benefit of lowering the dose slowly is that you may avoid withdrawal-type symptoms that many complain about. Such symptoms are reported to resolve within a few months. Many who aren't aware of this assume it's a return to hypogonadism and give up prematurely. It's good to recall that there is a threshold effect for hypogonadism; for the vast majority of men, symptoms will not occur if total testosterone reaches somewhere in the 400s ng/dL each day, assuming normal SHBG. I no longer use hCG, and even when I did, the production of endogenous testosterone seemed to be minimal. One reason why I need less testosterone is that I use a blend of testosterone enanthate and testosterone propionate, injected daily. Natural men have a diurnal rhythm, with serum testosterone highest in the early morning. The TE/TP blend attempts to mimic this to an extent. The hypothesis is that some benefits of testosterone derive from daily peak levels, whereas side effects are more driven by trough or average levels. This concept is supported by the clinical trials for Natesto. Many of these men have quite low baseline testosterone, but the three large, but relatively brief testosterone pulses each day are sufficient to resolve hypogonadism. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Do changes in body weight affect dose response?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top