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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
DMSO to increase absorption
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<blockquote data-quote="madman" data-source="post: 160057" data-attributes="member: 13851"><p><strong>Adverse reactions of dimethyl sulfoxide in humans: a systematic review [version 2; peer review: 2 approved] </strong></p><p></p><p></p><p></p><p></p><p><span style="color: rgb(184, 49, 47)"><strong>Abstract </strong></span></p><p></p><p><strong>Background:</strong> <strong><span style="color: rgb(184, 49, 47)">Dimethyl sulfoxide (DMSO) has been used for medical treatment and as a pharmacological agent in humans since the 1960s.</span></strong> <strong>Today, DMSO is used mostly for cryopreservation of stem cells, treatment of interstitial cystitis, <span style="color: rgb(184, 49, 47)">and as a penetrating vehicle for various drugs.</span> </strong>Many adverse reactions have been described in relation to the use of DMSO, but to our knowledge, no overview of the existing literature has been made. <strong><span style="color: rgb(26, 188, 156)">Our aim was to conduct a systematic review describing the adverse reactions observed in humans in relation to the use of DMSO.</span></strong></p><p></p><p><strong>Methods: </strong>This systematic review was reported according to the PRISMA-harms (Preferred Reporting Items for Systematic reviews and Meta-Analysis) guidelines. <strong><span style="color: rgb(184, 49, 47)">The primary outcome was any adverse reactions occurring in humans in relation to the use of DMSO.</span></strong> We included all original studies that reported adverse events due to the administration of DMSO, and that had a population of five or more.</p><p></p><p><strong>Results:</strong> <strong><span style="color: rgb(184, 49, 47)">We included a total of 109 studies. Gastrointestinal and skin reactions were the commonest reported adverse reactions to DMSO.</span></strong> <strong><span style="color: rgb(26, 188, 156)">Most reactions were transient without need for intervention. A relationship between the dose of DMSO given and the occurrence of adverse reactions was seen.</span></strong></p><p></p><p><strong><span style="color: rgb(0, 0, 0)">Conclusions:</span> <span style="color: rgb(184, 49, 47)">DMSO may cause a variety of adverse reactions that are mostly transient and mild. </span><span style="color: rgb(26, 188, 156)">The dose of DMSO plays an important role in the occurrence of adverse reactions. </span><span style="color: rgb(184, 49, 47)">DMSO seems to be safe to use in small doses.</span> </strong></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">In conclusion, adverse reactions due to DMSO are often mild and transient and do not qualify as serious adverse events.</span></strong> <span style="color: rgb(26, 188, 156)"><strong>Cardiovascular and respiratory adverse reactions occur mostly when DMSO is administered intravenously,</strong></span> <span style="color: rgb(44, 130, 201)"><strong>whereas dermatological reactions have a higher incidence when DMSO is administered transdermally.</strong></span><span style="color: rgb(0, 0, 0)"> <strong>An important finding is that the occurrence of adverse reactions seems to be related to the dose of DMSO, and it therefore seems safe to continue the use of DMSO in small doses.</strong></span></p></blockquote><p></p>
[QUOTE="madman, post: 160057, member: 13851"] [B]Adverse reactions of dimethyl sulfoxide in humans: a systematic review [version 2; peer review: 2 approved] [/B] [COLOR=rgb(184, 49, 47)][B]Abstract [/B][/COLOR] [B]Background:[/B] [B][COLOR=rgb(184, 49, 47)]Dimethyl sulfoxide (DMSO) has been used for medical treatment and as a pharmacological agent in humans since the 1960s.[/COLOR][/B] [B]Today, DMSO is used mostly for cryopreservation of stem cells, treatment of interstitial cystitis, [COLOR=rgb(184, 49, 47)]and as a penetrating vehicle for various drugs.[/COLOR] [/B]Many adverse reactions have been described in relation to the use of DMSO, but to our knowledge, no overview of the existing literature has been made. [B][COLOR=rgb(26, 188, 156)]Our aim was to conduct a systematic review describing the adverse reactions observed in humans in relation to the use of DMSO.[/COLOR][/B] [B]Methods: [/B]This systematic review was reported according to the PRISMA-harms (Preferred Reporting Items for Systematic reviews and Meta-Analysis) guidelines. [B][COLOR=rgb(184, 49, 47)]The primary outcome was any adverse reactions occurring in humans in relation to the use of DMSO.[/COLOR][/B] We included all original studies that reported adverse events due to the administration of DMSO, and that had a population of five or more. [B]Results:[/B] [B][COLOR=rgb(184, 49, 47)]We included a total of 109 studies. Gastrointestinal and skin reactions were the commonest reported adverse reactions to DMSO.[/COLOR][/B] [B][COLOR=rgb(26, 188, 156)]Most reactions were transient without need for intervention. A relationship between the dose of DMSO given and the occurrence of adverse reactions was seen.[/COLOR][/B] [B][COLOR=rgb(0, 0, 0)]Conclusions:[/COLOR] [COLOR=rgb(184, 49, 47)]DMSO may cause a variety of adverse reactions that are mostly transient and mild. [/COLOR][COLOR=rgb(26, 188, 156)]The dose of DMSO plays an important role in the occurrence of adverse reactions. [/COLOR][COLOR=rgb(184, 49, 47)]DMSO seems to be safe to use in small doses.[/COLOR] [/B] [B][COLOR=rgb(184, 49, 47)]In conclusion, adverse reactions due to DMSO are often mild and transient and do not qualify as serious adverse events.[/COLOR][/B] [COLOR=rgb(26, 188, 156)][B]Cardiovascular and respiratory adverse reactions occur mostly when DMSO is administered intravenously,[/B][/COLOR] [COLOR=rgb(44, 130, 201)][B]whereas dermatological reactions have a higher incidence when DMSO is administered transdermally.[/B][/COLOR][COLOR=rgb(0, 0, 0)] [B]An important finding is that the occurrence of adverse reactions seems to be related to the dose of DMSO, and it therefore seems safe to continue the use of DMSO in small doses.[/B][/COLOR] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
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DMSO to increase absorption
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