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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Diminished cholesterol efflux mediated by HDL and coronary artery disease in young male anabolic androgenic steroid users
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<blockquote data-quote="madman" data-source="post: 140621" data-attributes="member: 13851"><p><span style="font-size: 22px"><strong>Abstract</strong></span></p><p></p><p><span style="font-size: 18px"><strong><span style="color: rgb(184, 49, 47)">Background and aims</span></strong></span></p><p>Anabolic androgenic steroids (AAS) have been associated with coronary artery disease (CAD). AAS abuse leads to a remarkable decrease in high-density lipoprotein (HDL) plasma concentration, which could be a key factor in the atherosclerotic process. Moreover, not only the concentration of HDL, but also its functionality, plays a pivotal role in CAD. We tested the functionality of HDL by cholesterol efflux and antioxidant capacity. We also evaluated the prevalence of CAD in AAS users.</p><p></p><p><span style="font-size: 18px"><strong><span style="color: rgb(184, 49, 47)">Methods</span></strong></span></p><p>Twenty strength-trained AAS users (AASU) age 29 ± 5 yr, 20 age-matched strength-trained AAS nonusers (AASNU), and 10 sedentary controls (SC) were enrolled in this cross-sectional study. Functionality of HDL was evaluated by 14C-cholesterol efflux and the ability of HDL in inhibiting LDL oxidation. Coronary artery was evaluated with coronary computed tomography angiography.</p><p></p><p><span style="font-size: 18px"><strong><span style="color: rgb(184, 49, 47)">Results</span></strong></span></p><p>Cholesterol efflux was lower in AASU compared with AASNU and SC (20 <em>vs.</em> 23 <em>vs.</em> 24%, respectively, <em>p < </em>0.001). However, the lag time for LDL oxidation was higher in AASU compared with AASNU and SC (41 vs 13 vs 11 min, respectively, <em>p < </em>0.001). We found at least 2 coronary arteries with plaques in 25% of AASU. None of the AASNU and SC had plaques. The time of AAS use was negatively associated with cholesterol efflux.</p><p></p><p><span style="font-size: 18px"><strong><span style="color: rgb(184, 49, 47)">Conclusions</span></strong></span></p><p>This study indicates that AAS abuse impairs the cholesterol efflux mediated by HDL. Long-term AAS use seems to be correlated with lower cholesterol efflux and early subclinical CAD in this population.</p><p></p><p></p><p></p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/30826541" target="_blank">Diminished cholesterol efflux mediated by HDL and coronary artery disease in young male anabolic androgenic steroid users. - PubMed - NCBI</a></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p>[ATTACH=full]6933[/ATTACH]</p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><span style="font-size: 22px"><strong>Highlights</strong></span></p><p></p><ul> <li data-xf-list-type="ul"><strong><span style="color: rgb(184, 49, 47)">Anabolic androgenic steroids (AAS) abuse impairs the cholesterol efflux mediated by HDL.</span></strong></li> <li data-xf-list-type="ul"><span style="color: rgb(184, 49, 47)"><strong>AAS abuse seems to be correlated with lower cholesterol efflux and subclinical coronary artery disease (CAD).</strong></span></li> <li data-xf-list-type="ul"><strong><span style="color: rgb(184, 49, 47)">We found at least 2 coronary arteries with plaques in 25% of AAS users.</span></strong></li> </ul></blockquote><p></p>
[QUOTE="madman, post: 140621, member: 13851"] [SIZE=22px][B]Abstract[/B][/SIZE] [SIZE=18px][B][COLOR=rgb(184, 49, 47)]Background and aims[/COLOR][/B][/SIZE] Anabolic androgenic steroids (AAS) have been associated with coronary artery disease (CAD). AAS abuse leads to a remarkable decrease in high-density lipoprotein (HDL) plasma concentration, which could be a key factor in the atherosclerotic process. Moreover, not only the concentration of HDL, but also its functionality, plays a pivotal role in CAD. We tested the functionality of HDL by cholesterol efflux and antioxidant capacity. We also evaluated the prevalence of CAD in AAS users. [SIZE=18px][B][COLOR=rgb(184, 49, 47)]Methods[/COLOR][/B][/SIZE] Twenty strength-trained AAS users (AASU) age 29 ± 5 yr, 20 age-matched strength-trained AAS nonusers (AASNU), and 10 sedentary controls (SC) were enrolled in this cross-sectional study. Functionality of HDL was evaluated by 14C-cholesterol efflux and the ability of HDL in inhibiting LDL oxidation. Coronary artery was evaluated with coronary computed tomography angiography. [SIZE=18px][B][COLOR=rgb(184, 49, 47)]Results[/COLOR][/B][/SIZE] Cholesterol efflux was lower in AASU compared with AASNU and SC (20 [I]vs.[/I] 23 [I]vs.[/I] 24%, respectively, [I]p < [/I]0.001). However, the lag time for LDL oxidation was higher in AASU compared with AASNU and SC (41 vs 13 vs 11 min, respectively, [I]p < [/I]0.001). We found at least 2 coronary arteries with plaques in 25% of AASU. None of the AASNU and SC had plaques. The time of AAS use was negatively associated with cholesterol efflux. [SIZE=18px][B][COLOR=rgb(184, 49, 47)]Conclusions[/COLOR][/B][/SIZE] This study indicates that AAS abuse impairs the cholesterol efflux mediated by HDL. Long-term AAS use seems to be correlated with lower cholesterol efflux and early subclinical CAD in this population. [URL='https://www.ncbi.nlm.nih.gov/pubmed/30826541']Diminished cholesterol efflux mediated by HDL and coronary artery disease in young male anabolic androgenic steroid users. - PubMed - NCBI[/URL] [ATTACH=full]6933[/ATTACH] [SIZE=22px][B]Highlights[/B][/SIZE] [LIST] [*][B][COLOR=rgb(184, 49, 47)]Anabolic androgenic steroids (AAS) abuse impairs the cholesterol efflux mediated by HDL.[/COLOR][/B] [*][COLOR=rgb(184, 49, 47)][B]AAS abuse seems to be correlated with lower cholesterol efflux and subclinical coronary artery disease (CAD).[/B][/COLOR] [*][B][COLOR=rgb(184, 49, 47)]We found at least 2 coronary arteries with plaques in 25% of AAS users.[/COLOR][/B] [/LIST] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Diminished cholesterol efflux mediated by HDL and coronary artery disease in young male anabolic androgenic steroid users
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