ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
General Health & Fitness
Nutrition and Supplements
Diets and the use of Metformin
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="mcs" data-source="post: 255629" data-attributes="member: 12"><p>I am going on one year of my Metformin trial. I am not diabetic. I started it for its many benefits beyond its primary use as an anti-hyperglycemic agent. I started with 500mg b.i.d. of XR and went as high as 2g/day total, now at 1500mg. I, however, have it particularly weak in reducing my fasting BG and a1c compared to my pre-Metformin labs. In fact, it seems I am slightly higher on both insulin and glucose while ON the drug while my diet remained the same. I have a somewhat increased likelihood of treatment success with Metformin based on <a href="https://www.snpedia.com/index.php/Rs11212617(A;C)" target="_blank">my DNA</a>, so am not a complete non-responder.</p><p></p><p>Now when I stop or reduce the dose, my glucose levels increased significantly over my pre-Metformin baseline levels. It almost seems like rebound hyperglycemia once the body knows it's not getting its regular Metformin dose. I can only hypothesize it is from a liver dump of stored glucose from the drug that when stopped, gets released back into the bloodstream, causing a spike in glucose. Or perhaps it causes some type of negative feedback loop, messing with glucose/insulin regulation when stopped. Does anyone have an explanation for this?</p><p></p><p>I did notice a precipitous drop in both free and total T which I posted on before. I am not on TRT. I also wonder if it's caused loss of lean mass and V02 reduction since it suppresses mTOR, is anti-anabolic and inhibits the mitochondria. That's the only bad news. The good news is that I never had any of the commonly-reported gut-related symptoms. Since Metformin depletes B12, I monitor my levels and supplement so I remain at or above range.</p><p></p><p>For all the purported long-term benefits, I question whether I made a good choice and whether I should remain on the drug due to these short-term drawbacks.</p><p></p><p>Need some insight from experienced users.</p></blockquote><p></p>
[QUOTE="mcs, post: 255629, member: 12"] I am going on one year of my Metformin trial. I am not diabetic. I started it for its many benefits beyond its primary use as an anti-hyperglycemic agent. I started with 500mg b.i.d. of XR and went as high as 2g/day total, now at 1500mg. I, however, have it particularly weak in reducing my fasting BG and a1c compared to my pre-Metformin labs. In fact, it seems I am slightly higher on both insulin and glucose while ON the drug while my diet remained the same. I have a somewhat increased likelihood of treatment success with Metformin based on [URL='https://www.snpedia.com/index.php/Rs11212617(A;C)']my DNA[/URL], so am not a complete non-responder. Now when I stop or reduce the dose, my glucose levels increased significantly over my pre-Metformin baseline levels. It almost seems like rebound hyperglycemia once the body knows it's not getting its regular Metformin dose. I can only hypothesize it is from a liver dump of stored glucose from the drug that when stopped, gets released back into the bloodstream, causing a spike in glucose. Or perhaps it causes some type of negative feedback loop, messing with glucose/insulin regulation when stopped. Does anyone have an explanation for this? I did notice a precipitous drop in both free and total T which I posted on before. I am not on TRT. I also wonder if it's caused loss of lean mass and V02 reduction since it suppresses mTOR, is anti-anabolic and inhibits the mitochondria. That's the only bad news. The good news is that I never had any of the commonly-reported gut-related symptoms. Since Metformin depletes B12, I monitor my levels and supplement so I remain at or above range. For all the purported long-term benefits, I question whether I made a good choice and whether I should remain on the drug due to these short-term drawbacks. Need some insight from experienced users. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
General Health & Fitness
Nutrition and Supplements
Diets and the use of Metformin
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top