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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Did estrogen crash cause me permanent symptoms of low dopamine?
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<blockquote data-quote="keigwin" data-source="post: 79961" data-attributes="member: 16350"><p>I know you're not focusing on dopamine anymore, but I did want to post for anyone who finds this thread later and share my thoughts about how dopamine plays in all this. I had high E2 (40+ pg/mL) for about two years. I couldn't convince either my PCP or an endocrinologist that it was an issue that needed addressing. I had typical symptoms: low energy, low libido, weight gain, depression, etc. </p><p></p><p>This last spring, I had some symptoms that I suspected were due to taking the antidepressant bupropion. I'd been on it for about two years and recently had started experiencing tremors, especially in the hands and neck. After reviewing my meds, this seemed like a likely culprit so I cut my dosage. My symptoms improved. Then I decided (foolishly) that maybe I didn't need the bupropion at all and I just quit taking it. It's an NDRI, which means it keeps dopamine in your system longer, resulting in higher dopamine levels. One month after stopping it, I had ZERO libido and ZERO energy, was sleeping way too much, and couldn't get myself off the couch all day. Dopamine crash?</p><p></p><p>This was the point I decided to hell with the doctors and got my hormones retested on my own. I had not only high E2, but high prolactin 21.5 ng/mL (4.0-15.2). It turns out that dopamine plays an important role in regulating prolactin production. I went back on the bupropion and my prolactin came down a bit to 18.9 ng/mL after 4 weeks. It seemed the bupropion was helping my energy levels, but my libido was still ZERO. It was then I started anastrozole. My prolactin continued to come down, as did my E2. At the same time, my energy level improved dramatically and my libido returned. My most recent test had me at E2 17 pg/mL and prolactin 10.9 ng/mL. (Yes, I'm cutting back my anastrozole dosage).</p><p></p><p>I know it's a bit hard to separate things out since I started taking anastrozole only 4 weeks after restarting bupropion, but I strongly suspect a dopamine crash was involved and that going back on the antidepressant has played a significant role in bringing my hormones back in line. </p><p></p><p>Hope someone finds this helpful!</p></blockquote><p></p>
[QUOTE="keigwin, post: 79961, member: 16350"] I know you're not focusing on dopamine anymore, but I did want to post for anyone who finds this thread later and share my thoughts about how dopamine plays in all this. I had high E2 (40+ pg/mL) for about two years. I couldn't convince either my PCP or an endocrinologist that it was an issue that needed addressing. I had typical symptoms: low energy, low libido, weight gain, depression, etc. This last spring, I had some symptoms that I suspected were due to taking the antidepressant bupropion. I'd been on it for about two years and recently had started experiencing tremors, especially in the hands and neck. After reviewing my meds, this seemed like a likely culprit so I cut my dosage. My symptoms improved. Then I decided (foolishly) that maybe I didn't need the bupropion at all and I just quit taking it. It's an NDRI, which means it keeps dopamine in your system longer, resulting in higher dopamine levels. One month after stopping it, I had ZERO libido and ZERO energy, was sleeping way too much, and couldn't get myself off the couch all day. Dopamine crash? This was the point I decided to hell with the doctors and got my hormones retested on my own. I had not only high E2, but high prolactin 21.5 ng/mL (4.0-15.2). It turns out that dopamine plays an important role in regulating prolactin production. I went back on the bupropion and my prolactin came down a bit to 18.9 ng/mL after 4 weeks. It seemed the bupropion was helping my energy levels, but my libido was still ZERO. It was then I started anastrozole. My prolactin continued to come down, as did my E2. At the same time, my energy level improved dramatically and my libido returned. My most recent test had me at E2 17 pg/mL and prolactin 10.9 ng/mL. (Yes, I'm cutting back my anastrozole dosage). I know it's a bit hard to separate things out since I started taking anastrozole only 4 weeks after restarting bupropion, but I strongly suspect a dopamine crash was involved and that going back on the antidepressant has played a significant role in bringing my hormones back in line. Hope someone finds this helpful! [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Did estrogen crash cause me permanent symptoms of low dopamine?
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