ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Did estrogen crash cause me permanent symptoms of low dopamine?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="simeoni" data-source="post: 78204" data-attributes="member: 14463"><p>Long story short: Last fall I had my first "proper" estrogen crash with arimidex. The following months were a struggle for me when I tried to re-adjust my adex dose. Now I have to state that before that I had period of months were arimidex seemed to work just fine and I felt good. I did lose about 11 pounds after that so I guess that meant that I was aromatizing less. </p><p></p><p>Rewind to year 2017: Ive experienced 5-6 crashed during the past 7 months. According to my lab work, my E2 usually comes back in 7-10 days. </p><p></p><p>That said, the biggest thing that has been bothering me is the fact that since last november I have been experiencing strong apathy which is greatly hindering my every day life. There have been few weeks where I felt better, butt at the moment im feeling pretty horrible. </p><p></p><p>I feel that my symptoms are mainly realated to dopamine. They are:</p><p></p><p>- low libido - sometimes non existant</p><p>- cant really enjoy the things that I used to like</p><p>- I have a really low "drive" at the moment</p><p>- social interactions feel difficult </p><p>- Feel that my working memory is not the same anymore</p><p>- at worst I feel agitated</p><p>- I cant really handle stress</p><p></p><p>Overall my symptoms seem to resemble the early non-motor symptoms of parkinson's disease. Last november I made a thread here about a study that showed how an estrogen deprivation of 10-30 days lead to a 30% loss of dopamine producing neurons - in the substantia nigra. Now of course this was an animal study and a brief estrogen therapy (2 days) did restore the neurons in the animals that were deprived for 10 days. Here's the thread I mentioned: <a href="https://www.excelmale.com/forum/showthread.php?8891-Estrogen-crash-causing-permanent-apathy-lethargy-by-destroying-your-dopamine-neurons" target="_blank">https://www.excelmale.com/forum/showthread.php?8891-Estrogen-crash-causing-permanent-apathy-lethargy-by-destroying-your-dopamine-neurons</a></p><p></p><p>I guess my fear is that my current symptoms are permanent. Now I did have somewhat high e2 readings with my current protocol (54pg/ml on the non sensitive and 50 pg/ml on the sensitive). Because of that I did use an AI up until the 4th of july. After that I did however decide to ditch the AI completely and now Ive been "clean" for 4 weeks. Suprisingly on the latest non sensitive test I did not have a high reading - it was 38 pg/ml. Im still planning to go without an AI. Im hoping that the recovery time of 6-8 week's applies also for me.</p><p></p><p>Here are my latest labs and protocol.</p><p></p><p>Protocol: 0,15ml(37,5mg) TE E4D. I also take 5-7mg of testosterone gel on the scrotum ED or EOD.</p><p></p><p>Labs: </p><p></p><p>Androgens (2days after an injection):</p><p>TT: 840 ng/dl</p><p>SHBG: 25 nmol/l</p><p>FT:493 pmol/l (200-650 pmol/l)</p><p>E2: 38 pg/ml (non sensitive)</p><p></p><p>thyroid</p><p></p><p>TSH: 0,78 (0.3-4.5)</p><p>T4: 17 pmol/l (10-21)</p><p>T3: 5.1 pmol/l (3.2-6.5)</p><p></p><p>Iron status</p><p></p><p>Ferritin: 82 mq/l ( 20-250 )</p><p></p><p>Other labs</p><p></p><p>CRP: 1</p><p>Cortisol: 521 pmol/l (250-650 pmol/l)</p><p></p><p>So that's my current situation. Im wondering if there are any people here who have had similar experiences and eventually recovered - after a long period of having symptoms?</p><p></p><p>I know that my approach during last fall was stupid. I should have stopped adex after the first crash and waited for the usual 6-8 weeks. I took a long time to get it in my thick skull, that the only situations where you should introduce an AI should be after a high sensitive reading and persisting symptoms. Here's hoping it's not too late.</p><p></p><p>Also I want to keep this thread as a log on my road to recovery. I dont want to go forward alone. every advice is appriciated!</p></blockquote><p></p>
[QUOTE="simeoni, post: 78204, member: 14463"] Long story short: Last fall I had my first "proper" estrogen crash with arimidex. The following months were a struggle for me when I tried to re-adjust my adex dose. Now I have to state that before that I had period of months were arimidex seemed to work just fine and I felt good. I did lose about 11 pounds after that so I guess that meant that I was aromatizing less. Rewind to year 2017: Ive experienced 5-6 crashed during the past 7 months. According to my lab work, my E2 usually comes back in 7-10 days. That said, the biggest thing that has been bothering me is the fact that since last november I have been experiencing strong apathy which is greatly hindering my every day life. There have been few weeks where I felt better, butt at the moment im feeling pretty horrible. I feel that my symptoms are mainly realated to dopamine. They are: - low libido - sometimes non existant - cant really enjoy the things that I used to like - I have a really low "drive" at the moment - social interactions feel difficult - Feel that my working memory is not the same anymore - at worst I feel agitated - I cant really handle stress Overall my symptoms seem to resemble the early non-motor symptoms of parkinson's disease. Last november I made a thread here about a study that showed how an estrogen deprivation of 10-30 days lead to a 30% loss of dopamine producing neurons - in the substantia nigra. Now of course this was an animal study and a brief estrogen therapy (2 days) did restore the neurons in the animals that were deprived for 10 days. Here's the thread I mentioned: [URL]https://www.excelmale.com/forum/showthread.php?8891-Estrogen-crash-causing-permanent-apathy-lethargy-by-destroying-your-dopamine-neurons[/URL] I guess my fear is that my current symptoms are permanent. Now I did have somewhat high e2 readings with my current protocol (54pg/ml on the non sensitive and 50 pg/ml on the sensitive). Because of that I did use an AI up until the 4th of july. After that I did however decide to ditch the AI completely and now Ive been "clean" for 4 weeks. Suprisingly on the latest non sensitive test I did not have a high reading - it was 38 pg/ml. Im still planning to go without an AI. Im hoping that the recovery time of 6-8 week's applies also for me. Here are my latest labs and protocol. Protocol: 0,15ml(37,5mg) TE E4D. I also take 5-7mg of testosterone gel on the scrotum ED or EOD. Labs: Androgens (2days after an injection): TT: 840 ng/dl SHBG: 25 nmol/l FT:493 pmol/l (200-650 pmol/l) E2: 38 pg/ml (non sensitive) thyroid TSH: 0,78 (0.3-4.5) T4: 17 pmol/l (10-21) T3: 5.1 pmol/l (3.2-6.5) Iron status Ferritin: 82 mq/l ( 20-250 ) Other labs CRP: 1 Cortisol: 521 pmol/l (250-650 pmol/l) So that's my current situation. Im wondering if there are any people here who have had similar experiences and eventually recovered - after a long period of having symptoms? I know that my approach during last fall was stupid. I should have stopped adex after the first crash and waited for the usual 6-8 weeks. I took a long time to get it in my thick skull, that the only situations where you should introduce an AI should be after a high sensitive reading and persisting symptoms. Here's hoping it's not too late. Also I want to keep this thread as a log on my road to recovery. I dont want to go forward alone. every advice is appriciated! [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Did estrogen crash cause me permanent symptoms of low dopamine?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top