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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
DHT Gel Shuts Down LH, FSH, Estradiol and T But Sustained Sexual Function
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<blockquote data-quote="Nelson Vergel" data-source="post: 41194" data-attributes="member: 3"><p>From the paper (which is attached to this post). I do not agree with a few of these observations.</p><p></p><p></p><p>"Administration of nonaromatizable androgens such as DHT, nandrolone, or mesterolone may improve or at least not impair male sexual function. For example, in studies of sexual function, oral DHT undecanoate treatment of agonadal men maintains sexual function for 9 weeks [31], whereas sexual function was also improved more than placebo with daily DHT gel administration for 6 months to men with andropause symptoms and serum T<15 nmol/L [32]. Among studies of at least 1 month duration where adverse effects on sexual function may have led to discontinuations, no spontaneous complaints were reported in placebo- controlled studies of 1 [33] or 3 [34] months duration, a crossover study of 1 month duration [35] as well as uncontrolled studies of 5 months [36] or 3 months [37] duration. Similar observations apply to nandrolone, another potent androgen that is minimally or not aromatized in vitro [38] or in vivo [39,40]. When administered to men with HIV and weight loss, nandrolone improved sexual function more than placebo [41], whereas other placebo- controlled studies of nandrolone administration of at least 1 month duration reported no spontaneous complaints of adverse effects on sexual function [42&#8211;44]. Similar effects are reported with a nandrolone analog, 7&#945; methyl nandrolone [45].</p><p></p><p>Furthermore, the widespread illicit abuse of nandrolone by bodybuilders is not accompanied by complaints of sexual dysfunction. Finally, administration of 100 mg mesterolone, an oral DHT analog, daily for 4 weeks improves sexual function of hypogonadal men [46]. In the latter double- blind study although mesterolone was less effective than 120 mg oral T undecanoate, mesterolone effects may have been underestimated in the absence of a known dose-response for mesterolone through possibly using a suboptimal dose.</p><p></p><p>Furthermore, the aromatization hypothesis that male sexual function is estrogen dependent pre- dicts that estrogen receptor blockade may be detrimental to male sexual function. However, estrogen receptor blockers such as clomiphene, tamoxifen, raloxifene, or other mixed estrogen receptor agonist/antagonists have long been used off-label to treat men complaining of andropause, gynecomastia, infertility, and androgen abuse- induced hypogonadism. Although there are no speci&#64257;c studies of male sexual function, the best available evidence suggests that antiestrogen treatment does not impair male sexual function [47&#8211;53]."</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 41194, member: 3"] From the paper (which is attached to this post). I do not agree with a few of these observations. "Administration of nonaromatizable androgens such as DHT, nandrolone, or mesterolone may improve or at least not impair male sexual function. For example, in studies of sexual function, oral DHT undecanoate treatment of agonadal men maintains sexual function for 9 weeks [31], whereas sexual function was also improved more than placebo with daily DHT gel administration for 6 months to men with andropause symptoms and serum T<15 nmol/L [32]. Among studies of at least 1 month duration where adverse effects on sexual function may have led to discontinuations, no spontaneous complaints were reported in placebo- controlled studies of 1 [33] or 3 [34] months duration, a crossover study of 1 month duration [35] as well as uncontrolled studies of 5 months [36] or 3 months [37] duration. Similar observations apply to nandrolone, another potent androgen that is minimally or not aromatized in vitro [38] or in vivo [39,40]. When administered to men with HIV and weight loss, nandrolone improved sexual function more than placebo [41], whereas other placebo- controlled studies of nandrolone administration of at least 1 month duration reported no spontaneous complaints of adverse effects on sexual function [42–44]. Similar effects are reported with a nandrolone analog, 7α methyl nandrolone [45]. Furthermore, the widespread illicit abuse of nandrolone by bodybuilders is not accompanied by complaints of sexual dysfunction. Finally, administration of 100 mg mesterolone, an oral DHT analog, daily for 4 weeks improves sexual function of hypogonadal men [46]. In the latter double- blind study although mesterolone was less effective than 120 mg oral T undecanoate, mesterolone effects may have been underestimated in the absence of a known dose-response for mesterolone through possibly using a suboptimal dose. Furthermore, the aromatization hypothesis that male sexual function is estrogen dependent pre- dicts that estrogen receptor blockade may be detrimental to male sexual function. However, estrogen receptor blockers such as clomiphene, tamoxifen, raloxifene, or other mixed estrogen receptor agonist/antagonists have long been used off-label to treat men complaining of andropause, gynecomastia, infertility, and androgen abuse- induced hypogonadism. Although there are no specific studies of male sexual function, the best available evidence suggests that antiestrogen treatment does not impair male sexual function [47–53]." [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
DHT Gel Shuts Down LH, FSH, Estradiol and T But Sustained Sexual Function
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