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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
DHT Gel Effectively Treats Gynecomastia in HIV + Men
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<blockquote data-quote="sbstrum_MD" data-source="post: 97256" data-attributes="member: 17682"><p>In a patient with gynecomastia I would first check baseline serum prolactin and estradiol (E2), and then consider the use of prescription tamoxifen at 50 mg/d, and/or additional use of a prolactin inhibitor like cabergoline in an attenuated dose like 0.25 mg two to three times a week. This should work in the vast majority of men with gynecomastia. I am not sure why DHT would work to &#8595; gynecomastia. See below from Wikipedia. </p><p></p><p>Unlike other androgens such as testosterone, DHT cannot be converted by the enzyme aromatase into an estrogen like estradiol. Therefore, it is frequently used in research settings to distinguish between the effects of testosterone caused by binding to the AR and those caused by testosterone's conversion to estradiol and subsequent binding to and activation of ERs.[50] Although DHT cannot be aromatized, <u>it is still transformed into metabolites with significant ER affinity</u> and activity.[16] These are 3&#945;-androstanediol and 3&#946;-androstanediol, which are predominant <u>agonists</u> of the ER&#946;.[16]</p></blockquote><p></p>
[QUOTE="sbstrum_MD, post: 97256, member: 17682"] In a patient with gynecomastia I would first check baseline serum prolactin and estradiol (E2), and then consider the use of prescription tamoxifen at 50 mg/d, and/or additional use of a prolactin inhibitor like cabergoline in an attenuated dose like 0.25 mg two to three times a week. This should work in the vast majority of men with gynecomastia. I am not sure why DHT would work to ↓ gynecomastia. See below from Wikipedia. Unlike other androgens such as testosterone, DHT cannot be converted by the enzyme aromatase into an estrogen like estradiol. Therefore, it is frequently used in research settings to distinguish between the effects of testosterone caused by binding to the AR and those caused by testosterone's conversion to estradiol and subsequent binding to and activation of ERs.[50] Although DHT cannot be aromatized, [U]it is still transformed into metabolites with significant ER affinity[/U] and activity.[16] These are 3α-androstanediol and 3β-androstanediol, which are predominant [U]agonists[/U] of the ERβ.[16] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
DHT Gel Effectively Treats Gynecomastia in HIV + Men
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