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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
DHT Gel Effectively Treats Gynecomastia in HIV + Men
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<blockquote data-quote="Nelson Vergel" data-source="post: 125438" data-attributes="member: 3"><p><strong><a href="https://www.ncbi.nlm.nih.gov/pubmed/11932266#" target="_blank">Send to</a></strong></p><p></p><p></p><p></p><p></p><p>J Clin Endocrinol Metab. 2002 Apr;87(4):1467-72.</p><p><span style="font-size: 26px"><strong>The effects of transdermal dihydrotestosterone in the aging male: a prospective, randomized, double blind study.</strong></span></p><p></p><p></p><p><span style="font-size: 18px"><strong>Abstract</strong></span></p><p>The objective of the study was to investigate the effects of dihydrotestosterone (DHT) gel on general well-being, sexual function, and the prostate in aging men. A total of 120 men participated in this randomized, placebo-controlled study (60 DHT and 60 placebo). All subjects had nocturnal penile tumescence once per week or less, andropause symptoms, and a serum T level of 15 nmol/liter or less and/or a serum SHBG level greater than 30 nmol/liter. The mean age was 58 yr (range, 50-70 yr). Of these subjects, 114 men completed the study. DHT was administered transdermally for 6 months, and the dose varied from 125-250 mg/d. General well-being symptoms and sexual function were evaluated using a questionnaire, and prostate symptoms were evaluated using the International Prostate Symptoms Score, transrectal ultrasonography, and assay of serum prostate-specific antigen. Early morning erections improved transiently in the DHT group at 3 months of treatment (P < 0.003), and the ability to maintain erection improved in the DHT group compared with the placebo group (P < 0.04). No significant changes were observed in general well-being between the placebo and the DHT group.<strong> Serum concentrations of LH, FSH, E2, T, and SHBG decreased significantly during DHT treatment. </strong>Treatment with DHT did not affect liver function or the lipid profile. Hemoglobin concentrations increased from 146.0 +/- 8.2 to 154.8 +/- 11.4 g/liter, and hematocrit from 43.5 +/- 2.5% to 45.8 +/- 3.4% (P < 0.001). Prostate weight and prostate-specific antigen levels did not change during the treatment. No major adverse events were observed. Transdermal administration of DHT improves sexual function and may be a useful alternative for androgen replacement. As estrogens are thought to play a role in the pathogenesis of prostate hyperplasia, DHT may be beneficial, compared with aromatizing androgens, in the treatment of aging men.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 125438, member: 3"] [B][URL='https://www.ncbi.nlm.nih.gov/pubmed/11932266#']Send to[/URL][/B] J Clin Endocrinol Metab. 2002 Apr;87(4):1467-72. [SIZE=26px][B]The effects of transdermal dihydrotestosterone in the aging male: a prospective, randomized, double blind study.[/B][/SIZE] [SIZE=18px][B]Abstract[/B][/SIZE] The objective of the study was to investigate the effects of dihydrotestosterone (DHT) gel on general well-being, sexual function, and the prostate in aging men. A total of 120 men participated in this randomized, placebo-controlled study (60 DHT and 60 placebo). All subjects had nocturnal penile tumescence once per week or less, andropause symptoms, and a serum T level of 15 nmol/liter or less and/or a serum SHBG level greater than 30 nmol/liter. The mean age was 58 yr (range, 50-70 yr). Of these subjects, 114 men completed the study. DHT was administered transdermally for 6 months, and the dose varied from 125-250 mg/d. General well-being symptoms and sexual function were evaluated using a questionnaire, and prostate symptoms were evaluated using the International Prostate Symptoms Score, transrectal ultrasonography, and assay of serum prostate-specific antigen. Early morning erections improved transiently in the DHT group at 3 months of treatment (P < 0.003), and the ability to maintain erection improved in the DHT group compared with the placebo group (P < 0.04). No significant changes were observed in general well-being between the placebo and the DHT group.[B] Serum concentrations of LH, FSH, E2, T, and SHBG decreased significantly during DHT treatment. [/B]Treatment with DHT did not affect liver function or the lipid profile. Hemoglobin concentrations increased from 146.0 +/- 8.2 to 154.8 +/- 11.4 g/liter, and hematocrit from 43.5 +/- 2.5% to 45.8 +/- 3.4% (P < 0.001). Prostate weight and prostate-specific antigen levels did not change during the treatment. No major adverse events were observed. Transdermal administration of DHT improves sexual function and may be a useful alternative for androgen replacement. As estrogens are thought to play a role in the pathogenesis of prostate hyperplasia, DHT may be beneficial, compared with aromatizing androgens, in the treatment of aging men. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
DHT Gel Effectively Treats Gynecomastia in HIV + Men
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